摘要
目的研究Runx3、p27蛋白在胃癌组织中的表达以及与胃癌生物学行为的关系。方法应用免疫组化SABC方法,检测Runx3、p27蛋白在8例正常胃黏膜、15例异型增生、47例胃癌组织中的表达。结果(1)Runx3和p27在正常胃黏膜、异型增生及胃癌组织中的阳性表达率分别为87.5%、53.3%、36.2%和87.5%、66.7%、44.7%;Runx3的表达与胃癌的组织学类型、侵袭深度、淋巴结转移相关(P<0.05),p27的表达与胃癌侵袭深度、肿瘤临床分期及淋巴结转移相关(P<0.05)。(2)Runx3与p27在正常胃黏膜(P<0.025,r=0.5852)和胃癌组织中的表达呈正相关(P<0.05,r=0.4264)。结论Runx3、p27表达在胃癌的发生、发展中起着不同程度的作用,联合检测Runx3和p27蛋白的表达更能反映胃癌的生物学行为,优于单项检测。
Purpose To investigate the expression of Runx3 and p27 proteins in gastric carcinoma, and their relationship to the biological behavior of gastric carcinoma. Methods The expression of Runx3 and p27 was determined by immunohistochemistry SABC method in 8 cases of normal gastric mucosa tissue, 15 atypical hyperplasia of gastric mucosa, and 47 cases gastric carcinoma. Results （ 1 ） The positive expression rates of Runx3 and p27 were 87.5% , 53.3% , 36. 2% and 87.5% , 66. 7% , 44. 7% in gastric carcinoma, atypical hyperplasia and normal gastric mucosa, respectively. The expression of Runx3 was positively correlated with the histological type, depth of tumor infiltration, lymph node metastasis （ P 〈 0. 05 ） ; the expression of p27 was also positively correlated with the depth of tumor infiltration, clinical stage and lymph node metastasis （ P 〈 0. 05 ）. （2） There was a positive correlation between the expression Runx3 and p27 in normal gastric mucosa（P 〈0. 025 ,r =-0. 585 2）and gastric carcinoma tissue （P 〈0.05 ,r =0. 426 4）. Conclusions Runx3,p27 may play Certain roles in the carcinogenesis and progression of gastric carcinoma,and combined detection for Runx3 and p27 expression could reflect the malignant biological bebaviour of gastric carcinoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2009年第1期66-69,共4页
Chinese Journal of Clinical and Experimental Pathology
