摘要
C6细胞是大鼠经化学致癌剂N-亚硝基甲脲体内诱发产生的脑胶质瘤细胞,具有较典型的人脑胶质瘤组织学特点。大鼠脑内立体定向接种C6细胞建立的动物模型,因成瘤高、动物手术死亡率低,所以广泛应用于脑胶质瘤治疗的研究中。国外研究发现,来源于非纯种大鼠的C6细胞具有很强的免疫原性:其主要组织相容性基因复合体中存在与大鼠呈异源性的基因;C6细胞接种于大鼠体内引发强烈的免疫排斥反应可使肿瘤不能持续生长甚至自行消退,因此混淆了治疗所产生的效应,尤其当用于免疫和基因免疫治疗的研究时,存在较大缺陷。
The C6 glioma cell line was induced in rats through transplacental exposure to N-nitrosomethylurea and displayed the typical histologic features of human glioma. The C6 rat intracerebral glioma model constructed by stereotactic implantation technique has been employed extensively in glioma therapeutic studies for its good intracerebral grovvth yields and low mortality rate. It has recently been reported internationally that C6 glioma induced in an outbred Wistar rat, demonstrated strong immunogenicity and allogeneic MHC to rat strains. The intensive anti-C6 allogeneic graft rejection immune responses can have a significant impact on tumor grovvth in rats and can mimic therapeutic effects. There are limitations to the animal model in its employment to the glioma therapeutic studies, especially in immune and genetic therapy.
出处
《中华神经医学杂志》
CAS
CSCD
2003年第2期154-156,共3页
Chinese Journal of Neuromedicine
基金
广东省自然科学基金资助(001122)
