摘要
目的:通过应用伽玛刀对C6大鼠脑胶质瘤的治疗,检测治疗前后反映血管生成情况的血管内皮生长因子(VEGF)、反映细胞增殖情况的增殖细胞核抗原(PCNA)等的动态变化规律以及它们与凋亡的关系,探讨这些治疗效应在放射外科中的意义。方法:应用免疫组化及细胞凋亡方法进行统计学分析。结果:治疗后VEGF和PCNA表达降低,凋亡率明显高于对照组。结论:伽玛刀对于大鼠脑胶质瘤有明显的治疗作用。
Objective:The aim of our study is to evalute the changes of PCNA、VEGF and apoptosis at different time after the treatment of gamma knife and explore the significance of these changes in SRS as well as provide theoretical base for gamma knife treat brain glioma.Methods:Observe the VEGF、PCNA and apoptosis at different time with immunohistochemistry technique.Results:1.The expression of PCNA and VEGF decreased gradually with the increasing of time.The rate of apoptosis in the treatment group is higher than tha...
出处
《脑与神经疾病杂志》
2008年第3期181-184,共4页
Journal of Brain and Nervous Diseases
关键词
胶质瘤
伽玛刀
血管内皮生长因子
增殖细胞核抗原
Glioma Gamma knife Vascular endothelial growth factor（VEGF）Proliferating cell nuclear antigen（PCNA）Apoptosis
