摘要
工业和农业产生的有毒化学物质暴露于人体而发生肝损伤是最为常见的器官损伤。人或动物接触这些毒物会产生肝细胞坏死、硬化、纤维化,甚至引发肝癌。研究表明,植物、动物和微生物来源的天然多糖对多种化学毒物诱发的肝损伤模型动物具有很好的预防和治疗效果。这些活性多糖灌胃给药,对四氯化碳、D-半乳糖胺、脂多糖、二甲基亚硝铵及重金属镉诱导的动物化学性肝损伤有明显的保护或改善作用。本文将这些活性多糖抗化学性肝损伤的文献进行归纳,以期待今后开发多糖类药品或功能食品,用于肝损伤的预防和治疗。
Hepatotoxicity is the most common organ injury due to occupational and environmental exposure to industrial and agricultural toxical chemicals.A wide range of liver pathologies ranging from cell necrosis to cirrhosis,fibrosis and cancer have been observed following chemical exposure both in humans and in animal models.Considerable literature has shown that natural polysaccharides from plants,animals and microorganisms exhibited significant prophylactic and protective effects on chemical-induced hepatic injuries.These active polysaccharides extracted from different materials were treated and exhibited significant protective and therapeutical effects on CCl4-,D-galactosamine-,LPS-,nitrosodimethylamine-or cadmium-induced hepatic injury animal model.We summarize in this review the published polysaccharides and their pharmacologic activities for liver-protection.Therefore,some hepato-protective candidates might be found and developed as drugs or functional foods from these active polysaccharides in future.
作者
瞿文生
尹继业
高月求
周振华
单俊杰
QU Wen-sheng;YIN Ji-ye;GAO Yue-qiu;ZHOU Zhen-hua;SAHN Jun-jie(Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China;Department of Liver Disease,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2018年第12期885-898,共14页
Journal of International Pharmaceutical Research
基金
国家“十三五”重大新药创制专项课题资助项目(2017ZX10725-504)
关键词
天然多糖
化学性肝损伤
动物模型
化学毒物
预防和治疗
natural polysaccharides
chemical-induced liver damage
animal model
toxical chemicals
protection and therapy
