摘要
目的探讨扩张型心肌病(dilated cardiomyopathy,DCM)患者血清25-羟维生素D[25 hydroxy vitamin D,25(OH)D]、系统免疫炎症指数(systemic immune-inflammation index,SII)变化,分析两者与DCM病情严重程度的相关性。方法纳入2020年6月—2023年6月三明市第二医院心内科收治的104例DCM患者作为DCM组,健康体检者104名作为对照组。对比两组生化指标、血压、心脏功能指标、N末端B型脑钠肽前体、25(OH)D、SII差异。根据心功能分级将DCM分成心功能Ⅱ、Ⅲ、Ⅳ级组,按Lee氏心衰积分将DCM分成轻度心力衰竭、中度心力衰竭与重度心力衰竭组,对比各组25(OH)D、SII的差异。Pearson法分析25(OH)D、SII与心功能指标的相关性。受试者工作特征曲线分析25(OH)D、SII对DCM严重程度的评估价值。结果DCM组甘油三酯(triglyceride,TG)(1.77±0.37)mmol/L、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)(2.84±0.81)mmol/L、收缩压(124.23±8.87)mmHg、舒张压(78.44±8.28)mmHg、N末端B型脑钠肽前体(N-terminal B-type brain natriuretic peptide precursor,NT-proBNP)(1509.55±444.53)pg/mL、SII(897.54±107.89)×10^(9)/L、左心房收缩期末内径(left atrial end-systolic diameter,LAD)(45.92±7.17)mm、左心室舒张末期内径(left ventricular end-diastolic diameter,LVEDD)(64.53±7.10)mm、左心室收缩末期容积(left ventricular end-systolic volume,LVESV)(57.23±4.50)mL、左心室舒张末期容积(left ventricular end-diastolic volume,LVEDV)(87.85±9.38)mL,均高于对照组的(1.63±0.38)mmol/L、(2.53±0.56)mmol/L、(120.39±7.71)mmHg、(74.50±7.60)mmHg、(78.88±10.33)pg/mL、(309.66±59.69)×10^(9)/L、(28.02±3.53)mm、(44.47±2.59)mm、(31.78±3.80)mL、(63.50±4.43)mL,差异有统计学意义(P<0.001);DCM组白蛋白(37.30±3.81)g/L、25(OH)D(28.96±4.31)ng/mL、LVEF(33.97±5.42)%,均低于对照组的(43.10±2.93)g/L、(66.79±5.33)ng/mL、(66.01±6.19)%,差异均有统计学意义(P<0.001)。随着心功能分级、Lee氏心力衰竭积�
Objective To investigate the levels of serum 25 hydroxyvitamin D[25(OH)D]and systemic immune-inflammation index(SII)in the patients with dilated cardiomyopathy(DCM),and analysis the evaluation value of 25(OH)D and SII in the severity and prognosis of DCM.Methods A total of 104 DCM patients admitted to the department of cardiology,the Second Hospital of Sanming from June 2020 to June 2023 were included as the DCM group,and 104 healthy examinees were included as the control group.The differences in biochemical indicators,blood pressure,cardiac function indicators,N-terminal B-type natriuretic peptide precursor,25(OH)D,and SII between two groups were compared.According to the classification of heart function,DCM was divided into heart function level Ⅱ,Ⅲ and Ⅳ.According to Lee's heart failure score,DCM was divided into mild heart failure,moderate heart failure,and severe heart failure groups,and the differences in 25(OH)D and SII between the groups were compared.Pearson method was used to analyze the correlation between 25(OH)D,SII and cardiac function indicators.The evaluation value of 25(OH)D and SII in assessing the severity of DCM were analyzed by the working characteristic curves of subjects.Results In the DCM group,the levels of triglyceride(TG)was(1.77±0.37)mmol/L,low density lipoprotein cholesterol,(LDL-C)(2.84±0.81)mmol/L,systolic blood pressure(124.23±8.87)mmHg,diastolic blood pressure(78.44±8.28)mmHg,N-terminal B-type brain natriuretic peptide precursor(NT-proBNP)(1509.55±444.53)pg/mL,SII(897.54±107.89)×10^(9)/L,left atrial end-systolic diameter,(LAD)(45.92±7.17)mm,left ventricular end-diastolic diameter(LVEDD)(64.53±7.10)mm,left ventricular end-systolic volume(LVESV)(57.23±4.50)mL,left ventricular end-diastolic volume(LVEDV)(87.85±9.38)mL,which were higher than the levels of(1.63±0.38)mmol/L,(2.53±0.56)mmol/L,(120.39±7.71)mmHg,(74.50±7.60)mmHg,(78.88±10.33)pg/mL,(309.66±59.69)×10^(9)/L,(28.02±3.53)mm,(44.47±2.59)mm,(31.78±3.80)mL,(63.50±4.43)mL in the control group,the differen
作者
温冬梅
杨阳
王传辉
乐兴丁
张世袍
WEN Dongmei;YANG Yang;WANG Chuanhui;LE Xingding;ZHANG Shipao(Department of Cardiology,the Second Hospital of Sanming,Yong'an Fujian 366000,China)
出处
《中国卫生标准管理》
2024年第21期95-99,103,共6页
China Health Standard Management
