摘要
股骨头坏死(osteonecrosis of the femoral head,ONFH)是骨科常见病和难治性疾病,发病机制为股骨头血供受损或中断引起股骨头缺血、坏死,最终出现股骨头塌陷、关节功能障碍等症状。研究调查显示ONFH发病人数呈逐年上升趋势,好发于30~65岁人群,并逐渐趋于年轻化,其中30%~70%的病例出现双侧股骨头坏死,严重影响患者的生活[1]。按照病因ONFH主要分为创伤性股骨头坏死(traumatic-induced osteonecrosis of femoral head,TIONFH)和非创伤性股骨头坏死(non-traumatic osteonecrosis of the femoral head,NONFH),前者主要由股骨颈骨折、髋关节脱位等外伤引起,后者在我国的常见原因为糖皮质激素和酒精的过量使用[2]。
Osteonecrosis of the femoral head(ONFH)is one of the common diseases in orthopedics.The disease has complex pathogenic factors and high disability rate,which can eventually lead to structural changes of the femoral head,collapse of the femoral head,and hip joint dysfunction.With the development of high-throughput sequencing technology,many studies have shown that circular RNA(cirRNA)can regulate the osteogenesis and differentiation of bone marrow mesenchymal stem cells(BMSCs)through competing endogenous RNA(ceRNA)mechanism,and affect the occurrence and development of ONFH.In addition,circRNA is expected to become an ONFH diagnostic biomarker and participates in ONFH precision medicine as a therapeutic target.In this review,circRNA regulates osteogenic differentiation of BMSCs through ceRNA mechanism,and we discuss the role of this process in ONFH,in order to provide a new idea for diagnosis and treatment of ONFH.
作者
柳可心
刘凯
冬梅
王建忠
LIU Ke-xin;LIU Kai;DONG Mei;WANG Jian-zhong(Inner Mongolia Medical University,Hohhot,Inner Mongolia,010030,China)
出处
《中国骨与关节杂志》
CAS
2024年第3期219-224,共6页
Chinese Journal of Bone and Joint
基金
国家自然科学基金(81860401)
内蒙古自治区硕士研究生科研创新项目(S20231189Z)
内蒙古医科大学大学生创新创业训练计划项目(S202310132019X)
内蒙古医科大学“致远”人才计划(ZY110018)
内蒙古自治区科技计划(2022YFSH0075)。
