摘要
背景:股骨头坏死为骨科常见的致残性进展性疾病,其病情发展难以逆转,最终导致髋关节功能丧失,严重影响患者的生活质量。目的:对骨髓间充质干细胞治疗早期股骨头坏死的研究进展做一综述。方法:以“BMSCs,ONFH”为关键词检索PubMed英文数据库,以“骨髓间充质干细胞、股骨头坏死”为关键词检索CNKI、万方中文数据库。检索时限为2001年1月至2019年4月,排除与文章研究目的无关及重复性文章,纳入符合标准的42篇文献进行综述。结果与结论:骨髓间充质干细胞潜在修复股骨头,不仅提供修复前体细胞,还分泌细胞因子和生长因子,启动股骨头内细胞愈合过程。大量的实验与临床研究表明,骨髓间充质干细胞治疗早期股骨头坏死是一种可行的方法。
BACKGROUND:Femoral head necrosis is a common progressive disabling disease in orthopedics,and it is difficult to reverse disease progression.Eventually,the loss of hip function seriously impact patient’s quality of life.OBJECTIVE:To review the research progress of bone marrow mesenchymal stem cells in the treatment of femoral head necrosis.METHODS:The PubMed,CNKI and WanFang databases were searched for relevant articles with the keywords of“bone marrow mesenchymal stem cells,femoral head necrosis”in English and Chinese,respectively.The search time was from January 2001 to April 2019.Articles that were not related to the purpose of the research and repetitive articles were excluded,and 42 articles that met the criteria were finally included for review.RESULTS AND CONCLUSION:Bone marrow mesenchymal stem cells potentially repair the femoral head,not only providing precursor cells,but also secreting cytokines and growth factors and initiating cell healing in the femoral head.A large number of experimental and clinical studies have proved that bone marrow mesenchymal stem cells are available for the treatment of early femoral head necrosis.
作者
王田田
王建忠
Wang Tiantian;Wang Jianzhong(Inner Mongolia Medical University,Hohhot 010030,Inner Mongolia Autonomous Region,China;Department of Traumatic Orthopedics,Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,Inner Mongolia Autonomous Region,China)
出处
《中国组织工程研究》
CAS
北大核心
2020年第7期1117-1122,共6页
Chinese Journal of Tissue Engineering Research
关键词
股骨头坏死
骨髓间充质干细胞
髓芯减压
组织工程
综述
osteonecrosis of the femoral head
bone marrow mesenchymal stem cells
core decompression
tissue engineering
review
