摘要
目的探讨食管癌患者根治术后肺部感染的相关危险因素。方法回顾性分析120例食管癌患者临床资料。所有患者均接受食管癌根治术治疗,依据术后是否发生肺部感染分为感染组与未感染组,收集2组年龄、性别、体质量指数等基线资料,经Logistic回归分析,获取影响食管癌患者术后肺部感染发生的独立危险因素。结果120例患者共26例术后发生肺部感染,发生率为21.67%(26/120)。单因素分析显示,年龄、手术时间、术中出血量、术前白蛋白水平、手术通气方式、糖尿病、慢阻肺、吸烟史、术前肺功能与术后肺部感染发生有关(P<0.05),多因素分析显示,年龄≥65岁、手术时间≥4 h、术中出血量≥200 mL、术前白蛋白水平<30 g/L、单肺通气、糖尿病、慢阻肺、吸烟史、术前肺功能(FEV1/FVC)<70%为术后肺部感染发生的独立危险因素(P<0.05且OR>1)。结论食管癌患者根治术后肺部感染发生风险较高,且与年龄、手术时间、术中出血量、术前白蛋白水平等密切相关,临床需尽早开展针对性干预,减少肺部感染的发生。
Objective To investigate the relevant risk factors of pulmonary infection after radical surgery in patients with esophageal cancer.Methods The clinical data of 120 patients with oesophageal cancer were also retrospectively analyzed.All patients were treated with radical esophageal cancer,and were divided into infection and non-infection groups according to whether lung infection occurred after surgery.Baseline data of age,sex,body quality index and other data of the 2 groups were collected.Independent risk factors affecting the occurrence of postoperative lung infection in esophageal cancer patients were obtained by logistic regression analysis.Results A total of 26 postoperative pulmonary infections occurred in 120 patients,The incidence rate was 21.67%(26/120);The univariate analysis revealed that,age,operative time,intraoperative bleeding volume,preoperative albumin level,mode of surgical ventilation,diabetes mellitus,COPD,smoking history,and preoperative pulmonary function were associated with the occurrence of postoperative pulmonary infection,The difference was statistically significant(P<0.05);Multivariate analysis revealed that age≥65 years,operative time≥4 h,intraoperative bleeding volume≥200 mL,preoperative albumin level<30 g/L,single lung ventilation,diabetes,COPD,smoking history,and preoperative pulmonary function(FEV1/FVC)<70%were independent risk factors affecting the occurrence of postoperative pulmonary infection(P<0.05 and OR>1).Conclusion The risk of lung infection in esophageal cancer patients after radical surgery is high,which is closely related to age,operation time,intraoperative bleeding volume,and preoperative albumin level.Targeted clinical intervention should be carried out as early as possible to reduce the occurrence of lung infection.
作者
王乃馨
单单单
张继露
王贝
WANG Naixin;SHAN Dandan;ZHANG Jilu(Henan People's Hospital,Zhengzhou,450000)
出处
《实用癌症杂志》
2024年第2期233-236,共4页
The Practical Journal of Cancer
关键词
肺部感染
食管癌根治术
影响因素
Pulmonary infection
Radical resection of esophageal cancer
Influencing factors
