摘要
目的探讨中晚期食管鳞状细胞癌经同步放化疗患者发生肺部感染的病原学特点及危险因素,为临床诊疗提供参考依据。方法统计80例接受同步放化疗的中晚期食管鳞状细胞癌患者肺部感染的发生率和感染病原菌的类型,记录并分析患者的临床资料,探讨患者发生肺部感染的危险因素。结果80例中晚期食管鳞状细胞癌患者中,肺部感染的发生率为21.25%(17/80)。共检测出病原菌28株,其中,革兰阴性菌18株(64.29%),革兰阳性菌8株(28.57%),真菌2株(7.14%)。单因素分析结果显示,年龄、吸烟史、有无并发症可能与中晚期食管鳞状细胞癌患者经同步放化疗后发生肺部感染有关(P<0.05);多因素分析结果显示,年龄、吸烟史、有无并发症是中晚期食管鳞状细胞癌经同步放化疗后发生肺部感染的独立危险因素(P<0.05)。结论中晚期食管鳞状细胞癌患者经同步放化疗后发生肺部感染的病原菌以革兰阴性菌为主,年龄、吸烟史、有无并发症是中晚期食管鳞状细胞癌患者经同步放化疗后发生肺部感染的独立危险因素,应给予必要的护理措施以降低放化疗后肺部感染的发生率。
Objective To investigate the pathogenic characteristics and risk factors of patients with advanced esophageal squamous cell carcinoma(ESCC)suffering from pulmonary infection when receiving concurrent chemoradiotherapy(CCRT),and to provide a reference for clinical diagnosis and treatment.Method A total of 80 patients with ESCC who received CCRT were enrolled.The incidence of pulmonary infection,as well as the types of pathogenic bacteria,and their clinical data were recorded and analyzed.The risk factors for pulmonary infection were further investigated.Result Among 80 patients with advanced ESCC enrolled in the study,the incidence of pulmonary infection was 21.25%(17/80).A total of 28 pathogenic bacteria strains were detected,including 18 Gram-negative bacteria strains(64.29%),8 Grampositive bacteria strains(28.57%)and 2 fungi strains(7.14%).Univariate analysis showed that age,smoking history and complications could be related to pulmonary infection in patients with ESCC undergoing CCRT(P<0.05).Multivariate analysis indicated that age,smoking history and complications were also independent risk factors for pulmonary infection in patients with ESCC undergoing CCRT(P<0.05).Conclusion Gram-negative bacteria were the main pathogens of pulmonary infection in patients with ESCC undergoing CCRT.Age,smoking history and complications were independent risk factors for pulmonary infection in patients with ESCC after CCRT.Thereafter,fundamental nursing interventions should be considered for reducing the incidence of pulmonary infection after CCRT.
作者
陈静
侯海龙
CHEN Jing;HOU Hailong(Department of Tumor Radiotherapy,Central Hospital of Meihekou,Meihekou 135000,Jilin,China;Department of Respiratory Medicine,Central Hospital of Meihekou,Meihekou 135000,Jilin,China)
出处
《癌症进展》
2020年第12期1256-1258,1280,共4页
Oncology Progress
关键词
食管鳞状细胞癌
中晚期
同步放化疗
肺部感染
病原菌
危险因素
esophageal squamous cell carcinoma
advanced stage
concurrent chemoradiotherapy
pulmonary infection
pathogenic bacteria
risk factor
