摘要
目的:探讨慢性阻塞性肺疾病(COPD)急性加重期患者发生侵袭性肺曲霉菌感染的危险因素。方法:回顾性分析2018年9月-2021年10月萍乡矿业集团总医院收治的120例COPD急性加重期患者的临床资料,根据患者是否发生侵袭性肺曲霉菌感染将其分为感染组和未感染组。比较两组一般资料,并予以多因素logistic回归分析法分析COPD急性加重期患者发生侵袭性肺曲霉菌感染的危险因素。结果:120例COPD急性加重期患者发生侵袭性肺曲霉菌感染60例,感染率为50.00%。单因素分析结果显示,两组年龄、吸烟史、糖皮质激素使用时间、抗生素使用时间、住院时间、机械通气史、是否合并冠心病、是否合并糖尿病、是否合并低蛋白血症比较,差异均有统计学意义(P<0.05)。多因素logistic回归分析结果显示,年龄≥60岁[OR=3.873,95%CI(1.557,9.635)]、有吸烟史[OR=1.970,95%CI(1.044,3.717)]、糖皮质激素使用时间≥7 d[OR=6.449,95%CI(2.654,15.672)]、有机械通气史[OR=3.435,95%CI(1.609,7.334)]、合并糖尿病[OR=4.276,95%CI(2.046,8.935)]、合并低蛋白血症[OR=5.859,95%CI(1.895,18.119)]是COPD急性加重期患者发生侵袭性肺曲霉菌感染的独立危险因素(P<0.05)。结论:COPD急性加重期患者发生侵袭性肺曲霉菌感染的风险较高,其危险因素包括年龄≥60岁、有吸烟史、糖皮质激素使用时间≥7 d、有机械通气史、合并糖尿病、合并低蛋白血症等。
Objective:To investigate the risk factors of invasive pulmonary Aspergillus infection in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Method:The clinical data of 120 patients with acute exacerbation of COPD admitted to Pingxiang Mining Group General Hospital from September 2018 to October 2021 were retrospectively analyzed,according to whether invasive pulmonary aspergillus infection occurred in the patients,they were divided into infection group and non-infection group.The general data of the two groups were compared,and the risk factors of invasive pulmonary aspergillus infection in patients with acute exacerbation of COPD were analyzed by multivariate logistic regression analysis.Result:Invasive pulmonary aspergillus infection occurred in 60 of 120 patients with acute exacerbation of COPD,and the infection rate was 50.00%.Univariate analysis showed that there were statistically significant differences in age,smoking history,duration of glucocorticoid use,duration of antibiotic use,length of hospital stay,history of mechanical ventilation,coronary heart disease,diabetes mellitus and hypoproteinemia between the two groups(P<0.05).Multivariate logistic regression analysis showed that age≥60 years[OR=3.873,95%CI(1.557,9.635)],smoking history[OR=1.970,95%CI(1.557,9.635)],duration of glucocorticoid use≥7 d[OR=6.449,95%CI(2.654,15.672)],history of mechanical ventilation[OR=3.435,95%CI(1.609,7.334)],combined with diabetes mellitus[OR=4.276,95%CI(2.046,8.935)],combined with hypoproteinemia[OR=5.859,95%CI(1.895,18.119)]were independent risk factors for invasive pulmonary aspergillus infection in patients with acute exacerbation of COPD(P<0.05).Conclusion:Patients with acute exacerbation of COPD have higher risk of invasive pulmonary aspergillus infection,and the risk factors include age≥60 years old,smoking history,glucocorticoid use time≥7 d,history of mechanical ventilation,diabetes mellitus and hypoproteinemia,etc.
作者
杨羽
唐丽丽
尚静
黄江
李泽年
YANG Yu;TANG Lili;SHANG Jing;HUANG Jiang;LI Zenian(Pingxiang Health Vocational College,Pingxiang 337000,China;不详)
出处
《中国医学创新》
CAS
2022年第24期65-69,共5页
Medical Innovation of China
关键词
慢性阻塞性肺疾病
急性加重期
侵袭性肺曲霉菌感染
低蛋白血症
Chronic obstructive pulmonary disease
Acute exacerbation
Invasive pulmonary aspergillus infection
Hypoproteinemia
