摘要
特应性皮炎是一种常见的慢性复发性、瘙痒性、炎症性皮肤疾病,其发病率高且发病机制复杂。TRPV1为作为瞬时受体电位家族重要的一员参与了多种皮肤疾病的病理生理学及发病过程,近期研究证据亦发现TRPV1与特应性皮炎的发病机制密切的相关性,目前以TRPV1为主要靶标治疗特应性皮炎的药物取得了良好的疗效与安全性。本文就TRPV1在特应性皮炎发病机制和治疗中的研究进展进行综述。
Atopic dermatitis is a common chronic recurrent,itchy and inflammatory skin disease with high incidence rate and complex pathogenesis.TRPV1,as an important member of the transient receptor potential family,participates in the pathophysiology and pathogenesis of various skin diseases.Recent research evidence has also found a strong correlation between TRPV1 and the pathogenesis of atopic dermatitis.Currently,some drugs targeting TRPV1 have achieved good efficacy and safety in treating atopic dermatitis.The update of TRPV1 in the pathogenesis and treatment of atopic dermatitis is reviewed in this paper.
作者
燕红霞
花日
贾秀娟
王百灵
高志清
张小峰
吴凤兰
木其日
YAN Hongxia;HUA Ri;JIA Xiujuan;WANG Bailing;GAO Zhiqing;ZHANG Xiaofeng;WU Fenglan;MU Qiri(Department of Dermatology,International Mongolian Hospital of Inner Mongolia,Hohhot 010020,China;Department of Dermatology,Baotou Mongolian Medicine and Traditional Chinese Medicine Hospital,Baotou 014040,China;Inner Mongolia People s Hospital,Hohhot 010010,China;Traditional Chinese Medicine and Mongolian Medicine Research Center of Inner Mongolia,Hohhot 010060,China)
出处
《中国麻风皮肤病杂志》
2023年第10期770-773,共4页
China Journal of Leprosy and Skin Diseases
基金
内蒙古自治区自然科学基金重大项目(编号:2021ZD15)。
