摘要
特特应性皮炎是一种常见的慢性反复性瘙痒性皮肤疾病,瘙痒是其最明显、对患者影响最大的临床特征。缓解瘙痒症状对于控制特应性皮炎的病情尤其重要。但目前特应性皮炎瘙痒发生的病理生理学机制尚未完全清楚。该文对最近报道与特应性皮炎瘙痒有关的神经因素、致痒因子、皮肤屏障功能破坏和相互作用进行综述,为特应性皮炎瘙痒发生机制的进一步研究和治疗提供依据。
Atopic dermatitis is a common repetitive chronic pruritic skin disease,in which itching is the most obvious feature that affects patients'life.Relieving and controlling itching is especially significant for the treatment of atopic dermatitis.However,the pathophysiological mechanism of pruritus in atopic dermatitis is not yet clear.This article reviews the neurological factors,itch-causing factors,skin barrier function destruction and their interactions related to pruritus in atopic dermatitis,to provide evidence for further studies on the mechanism and treatment of itch in atopic dermatitis.
作者
罗玲玲
崔盘根
李诚让
LUO Ling-ling;CUI Pan-gen;LI Cheng-rang(Department of Dermatology,Hospital for Skin Disease,Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China)
出处
《实用皮肤病学杂志》
2022年第5期287-290,295,共5页
Journal of Practical Dermatology
基金
中国医学科学院医学与健康科技创新工程(2016-12M-1-002)。
关键词
皮炎
特应性
瘙痒
发病机制
Dermatitis,atopic
Pruritus
Pathogenesis
