摘要
目的探讨三维能量多普勒超声定量参数联合人附睾分泌蛋白4(HE4)、糖类抗原125(CA125)预测绝经后出血(PMB)女性子宫内膜癌(EC)的临床价值。方法选取于我院就诊的PMB女性157例,按照病理检查结果分为EC组49例、良性组65例、正常组43例,均行三维能量多普勒超声检查和实验室检查,比较各组超声定量参数和HE4、CA125的差异。绘制受试者工作特征(ROC)曲线分析各参数单独及联合应用预测PMB女性EC的诊断效能。结果EC组子宫内膜容积(EV)、血流指数(FI)、血管形成指数(VI)、血管形成-血流指数(VFI)、HE4、CA125均高于良性组和对照组,差异均有统计学意义(均P<0.05);良性组EV、FI、VI、VFI、HE4、CA125均高于对照组,差异均有统计学意义(均P<0.05)。ROC曲线分析显示,EV、FI、VI、VFI、HE4、CA125单独及联合应用预测PMB女性EC的曲线下面积分别为0.853、0.807、0.809、0.884、0.830、0.836、0.950,其中联合应用的诊断效能最高,对应的灵敏度、特异度分别为89.8%、87.0%。结论PMB女性EC患者三维能量多普勒超声定量参数EV、FI、VI、VFI均升高,且HE4、CA125均呈高表达,各参数联合应用有较好的预测价值。
Objective To explore the clinical value of three-dimensional power Doppler ultrasound quantitative parameters combined with human epididymal secretory protein 4(HE4)and carbohydrate polypeptide antigen 125(CA125)in predicting endometrial cancer(EC)in women with postmenopausal bleeding(PMB).Methods A total of 157 patients with PMB admitted in our hospital were selected and divided into EC group(49 cases),benign lesion group(65 cases),normal group(43 cases)according to pathological examination results.All patients underwent three-dimensional power Doppler ultrasound examination and laboratory serological examination,the differences of three-dimensional ultrasound quantitative parameters,HE4,CA125 among the groups were compared.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of parameters alone and in combination in predicting EC in women with PMB.Results Endometrial volume(EV),blood flow index(FI),angiogenesis index(VI),vascularization-blood flow index(VFI),HE4 and CA125 in EC group were significantly higher than those in benign group and control group,with statistical significances(all P<0.05),EV,FI,VI,VFI,HE4,CA125 in the benign group were significantly higher than those in the control group,with statistical significances(all P<0.05).ROC curve analysis showed that the areas under the curve of EV,FI,VI,VFI,HE4,CA125 alone and in combination in predicting EC in women with PMB were 0.853,0.807,0.809,0.884,0.830,0.836,0.950,respectively.The combined application had the highest diagnostic efficacy,with corresponding sensitivity and specificity of 89.8%and 87.0%.Conclusion Three-dimensional power Doppler ultrasound parameters EV,FI,VI,VFI in EC patients with PMB are increased,while HE4 and CA125 are highly expressed,the combined application of various parameters had good predictive value.
作者
章梦飞
欧英炜
郑双琴
任定远
王超
周倩茹
南勇
ZHANG Mengfei;OU Yingwei;ZHENG Shuangqin;REN Dingyuan;WANG Chao;ZHOU Qianru;NAN Yong(Department of Emergency Medicine,Zhejiang Provincial People’s Hospital,Hangzhou 310014,China)
出处
《临床超声医学杂志》
CSCD
2023年第7期567-570,共4页
Journal of Clinical Ultrasound in Medicine
关键词
超声检查
能量多普勒
三维
定量分析
人附睾分泌蛋白4
糖类抗原125
绝经后出血
子宫内膜癌
Ultrasonography,power Doppler,three-dimensional
Quantitative analysis
Human epididymal secretory protein 4
Carbohydrate polypeptide antigen 125
Postmenopausal bleeding
Endometrial cancer
