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醋酸甲羟孕酮联合TC化疗方案对子宫内膜癌患者术后血清HE4、VEGF水平变化的影响 被引量:8

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摘要 目的:观察醋酸甲羟孕酮联合TC化疗方案对子宫内膜癌患者术后血清人附睾分泌蛋白4(HE4)、血管内皮生长因子(VEGF水平变化的影响。方法:选取79例子宫内膜癌患者作为观察对象,按照随机数字表法将其分为对照组39例和观察组40例,对照组采用TC化疗方案治疗,观察组在对照组的基础上联合醋酸甲羟孕酮治疗,比较两组临床疗效及治疗前后血清VEGF、HE4水平的变化情况,并统计两组不良反应发生情况。结果:观察组临床缓解率为82.50%(33/40),明显高于对照组的61.54%(24/39),差异有统计学意义(P<0.05);治疗后观察组血清HE4、VEGF水平明显低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:醋酸甲羟孕酮联合TC化疗方案辅助手术治疗子宫内膜癌,效果显著,可下调患者血清HE4、VEGF水平,且安全可靠。
机构地区 安阳市肿瘤医院
出处 《中国民康医学》 2019年第7期82-84,共3页 Medical Journal of Chinese People’s Health
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