摘要
目的:探究E-钙黏附蛋白(E-cadherin)、糖类抗原199(CA199)及人附睾分泌蛋白E4(HE4)在子宫内膜异位症(endometriosis,EM)患者血清的表达及与自身抗体的相关性。方法:选取2017年12月至2019年12月于我院治疗的156例EM患者,根据AFS分期分为Ⅰ期(n=31)、Ⅱ期(n=42)、Ⅲ期(n=47)、Ⅳ期(n=36),另选取健康体检者50例作为对照组,对比各组患者血清内分泌激素、炎症因子、E-cadherin、CA199、HE4水平及自身抗体,分析E-cadherin、CA199及HE4水平与内分泌激素、炎性因子水平及自身抗体的相关性。结果:Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期及对照组患者血清雌二醇(E2)、泌乳素(PRL)、胰岛素(INS)水平比较,差异均有统计学意义(P<0.05);EM各分期患者血清卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)水平比较,差异均无统计学意义(P>0.05);EM患者血清FSH、LH、T水平均低于对照组(P<0.05)。Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期及对照组患者血清白细胞介素-1β(IL-1β)、白细胞介素-18(IL-18)、单核细胞趋化蛋白1(MCP-1)及肿瘤坏死因子-α(TNF-α)水平比较差异均有统计学意义(P<0.05)。EM各临床分期患者血清E-cadherin、CA199及HE4水平均较对照组升高,各组比较差异均有统计学意义(P<0.05)。Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期患者抗精子抗体(ASAb)、抗绒毛膜促性腺激素抗体(HCGAb)、抗卵巢抗体(AOAb)、抗心磷脂抗体(ACAb)、抗子宫内膜抗体(EMAb)总阳性率升高,各组比较差异具有统计学意义(P<0.05)。相关性分析结果显示,血清E-cadherin、CA199及HE4水平与E2、INS、FSH水平存在负相关性,与PRL、IL-1β、IL-18、MCP-1及TNF-α水平存在正相关性(P<0.05);E-cadherin、CA199及HE4水平与各自身免疫抗体阳性率存在正相关性(P<0.05)。结论:EM不同AFS分期患者血清内分泌激素、炎症因子水平及自身免疫抗体存在显著差异并与E-cadherin、CA199及HE4水平存在相关性,检测血清E-cadherin、CA199及HE4水平有助于了�
Objective: To investigate the expression of E-cadherin,carbohydrate antigen 199( CA199) and human epididymis secretory protein E4( HE4) in patients with endometriosis( EM) and their correlation with autoantibodies. Methods: 156 patients with EM who were treated in our hospital from December 2017 to December 2019 were selected. According to the AFS stage,they were divided into stage Ⅰ( n = 31),stage Ⅱ( n = 42),stage Ⅲ( n = 47),and Stage Ⅳ( n = 36). 50 healthy subjects were selected as the control group.The serum levels of endocrine hormones,inflammatory factors,E-cadherin,CA199,HE4 and autoantibodies were compared between each group. Correlation of the level of E-cadherin,CA199,HE4 and the level of endocrine hormones,inflammatory factors and autoantibodies were analyzed. Results: The serum levels of estradiol( E2),prolactin( PRL),and insulin( INS) of the patients in the stage Ⅰ group,stage Ⅱ group,stage Ⅲ group,stage Ⅳ group and the control group had statistical difference( P<0. 05). There was no statistical difference in the levels of follicle stimulating hormone( FSH),luteinizing hormone( LH),and testosterone( T) in the EM patients of different stages( P>0. 05). The serum levels of FSH,LH,and T of EM patients were lower than those in the control group( P<0. 05). The serum level of interleukin-1β( IL-1β),interleukin-18( IL-18),monocyte chemoattractant protein 1( MCP-1) and tumor necrosis factor-α( TNF-α) of EM patients in stage Ⅰ,stage Ⅱ,stage Ⅲ,stage Ⅳand the control group had statistical difference( P<0. 05). The serum levels of E-cadherin,CA199 and HE4 of EM patients of different stages were higher than those in the control group,and the differences between each groups were statistically significant( P<0. 05). The positive rate of anti-sperm antibody( ASAb),anti-chorionic gonadotropin antibody( HCGAb),anti-ovarian antibody( AOAb),anti-cardiolipin antibody( ACAb),and anti-endometrial antibody( EMAb) of EM patients in stage I,stage II,stage Ⅲ,and stage IV were obviously higher than
作者
张安能
杨慧健
孙宏超
ZHANG Anneng;YANG Huijian;SUN Hongchao(Shanghai Jiading District Anting Hospital,Shanghai 201805,China;Shanghai Dongfang Hospital(Southern Branch),Shanghai 200120,China)
出处
《中国医药导刊》
2021年第9期647-652,共6页
Chinese Journal of Medicinal Guide
基金
上海市卫生和计划生育委员会科研课题(项目编号:2018Y0087,项目名称:在HBV病毒慢性感染中Exosomes对MDSCs调节机制研究)。
