摘要
目的探讨益生菌辅助治疗子宫内膜异位症(EMs)的效果及对肠道菌群多样性的影响。方法选择2019年8月—2021年8月收治的EMs 126例,依据随机数字表法分为CG组、EG组,每组63例。CG组给予米非司酮片治疗,EG组在CG组基础上给予复方嗜酸乳杆菌片辅助治疗。比较2组临床疗效,分析2组治疗前后子宫血流动力学及内膜厚度、血清炎性因子、免疫功能标志物、肠道菌群多样性,并统计有妊娠需求患者的妊娠情况。结果治疗后,EG组治疗总有效率(93.65%,59/63),高于CG组总有效率(79.37%,50/63)(P<0.05)。治疗后,2组子宫动脉PI、RI水平及子宫内膜厚度较治疗前降低,且EG组低于CG组(P<0.05);治疗后,2组血清为肿瘤坏死因子-α、白细胞介素-8、白细胞介素-6水平较治疗前降低,且EG组低于CG组(P<0.05);治疗后,2组NK细胞、CD8+水平较治疗前升高,且EG组高于CG组(P<0.05),CD4+/CD8+、CD4+水平较治疗前降低,且EG组低于CG组(P<0.05);治疗后,2组肠道菌群丰富度、辛普森均匀度指数及香农-威纳多样性指数较治疗前升高,且EG组高于CG组(P<0.05)。EG组治疗后6、24个月有妊娠需求患者妊娠率高于CG组(P>0.05);EG组有妊娠需求患者总妊娠率(73.33%,22/30)高于CG组总妊娠率(42.86%,12/28)(P<0.05)。2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论益生菌治疗EMs患者具有协同辅助的效果,可调节肠道菌群多样性,提高临床治愈率,改善临床症状及机体免疫功能,降低炎症反应,有助于患者预后妊娠。
Objective To investigate the effect of probiotics in the adjuvant treatment of endometriosis(EMs)and its impact on intestinal flora diversity.Methods A total of 126 EMs patients treated from August 2019 to August 2021 were selected and divided into CG group and EG group according to random number table method,with 63 cases in each group.CG group was treated with Mifepristone tablets,and EG group was treated with compound Lactobacillus Acidophilus tablets based on CG group.The clinical efficacy of the two groups was compared,and the uterine hemodynamics,endometrial thickness,serum inflammatory factors,immune function markers,and intestinal flora diversity before and after treatment were analyzed in the two groups.In addition,the pregnancy status of patients with pregnancy needs was analyzed.Results After treatment,the total effective rate of EG group(93.65%,59/63)was higher than that of CG group(79.37%,50/63)(P<0.05).After treatment,pulsatility index(PI)and resistant index(RI)levels of uterine artery and endometrial thickness in the two groups were lower than those before treatment,and lower in EG group than in CG group(P<0.05).After treatment,the serum levels of tumor necrosis factor-α,interleukin-8 and interleukin-6 in the two groups were lower than those before treatment,and lower in EG group than in CG group(P<0.05).After treatment,NK cells and CD8+levels in the two groups were higher than those before treatment,which were higher in EG group than in CG group(P<0.05),while CD4+/CD8+and CD4+were lower than those before treatment,which were lower in EG group than in CG group(P<0.05).After treatment,intestinal flora richness,Simpson evenness index and Shannon-Wiener diversity index in the two groups were higher than those before treatment,which were higher in EG group than in CG group(P<0.05).The pregnancy rate in EG group with pregnancy needs was higher than that in CG group at 6 and 24 months after treatment(P>0.05).The total pregnancy rate of patients with pregnancy needs in EG group(73.33%,22/30)was lower tha
作者
王萍
刘亚
黄维
郝丽
成刚
王倩楠
彭嘉文
成少华
WANG Ping;LIU Ya;HUANG Wei;HAO Li;CHENG Gang;WANG Qiannan;PENG Jiawen;CHENG Shaohua(Department of Gynecology and Obstetrics,People's Hospital of Dingzhou City,Dingzhou,Hebei 073000,China;Department of Anesthesiology,People's Hospital of Dingzhou City,Dingzhou,Hebei 073000,China;Department of Ultrasound,Dingzhou Hospital of Traditional Chinese Medicine,Dingzhou,Hebei 073099,China)
出处
《临床误诊误治》
CAS
2024年第1期70-75,共6页
Clinical Misdiagnosis & Mistherapy
基金
2023年度河北省医学科学研究重点课题计划项目(20232204)。
