摘要
目的 研究益生菌联合蒙脱石散治疗抗生素相关腹泻(ADD)患儿对其肠道菌群、炎性因子及免疫功能的影响。方法 选取2021年02月-2023年02月期间80例ADD患儿随机分组,对照组40例采用蒙脱石散治疗,观察组40例联合益生菌治疗,对比两组患儿临床疗效、肠道菌群、炎性因子及免疫功能。结果 观察组治疗总有效率92.50%高于对照组75.00%(P<0.05);观察组治疗后,白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平分别为(40.30±3.41)ng/L、(23.10±3.40)ng/L、(35.26±3.96)ng/L,均低于对照组(45.63±3.68)ng/L、(33.20±3.25)ng/L、(43.60±4.15)ng/L(P<0.05);观察组治疗后,双歧杆菌、乳杆菌、真杆菌水平分别为(10.65±0.63)×10^(8)CFU/mL、(9.49±0.48)×10^(8)CFU/mL、(8.91±0.71)×10^(8)CFU/mL,均高于对照组(9.68±0.49)×10^(8)CFU/mL、(9.06±0.56)×10^(8)CFU/mL、(8.13±0.52)×10^(8)CFU/mL(P<0.05);观察组治疗后,免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)水平分别为(2.19±0.33)g/L、(11.59±1.50)g/L、(1.69±0.36)g/L,均高于对照组(1.79±0.30)g/L、(9.46±1.10)g/L、(1.40±0.33)g/L(P<0.05)。结论 益生菌联合蒙脱石散治疗ADD患儿效果确切,能够有效抑制炎症反应,维持肠道菌群平衡,提高免疫功能。
Objective To study the effects of probiotics combined with montmorillonite powder on intestinal flora,inflammatory factors and immune function in children with antibiotic-associated diarrhea(ADD).Methods From February 2021 to February 2023,80 cases of children with ADD in our hospital were randomly assigned,40 cases in the control group were treated with montmorillonite powder,and 40 cases in the observation group were treated with probiotics.The clinical efficacy,intestinal flora,inflammatory factors and immune function of the two groups were compared.Results The total effective rate of observation group was 92.50%higher than that of control group 75.00%(P<0.05).After treatment,the levels of interleukin-2(IL-2),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in observation group were(40.30±3.41)ng/L,(23.10±3.40)ng/L and(35.26±3.96)ng/L,respectively.It was lower than that of control group(45.63±3.68)ng/L,(33.20±3.25)ng/L,(43.60±4.15)ng/L(P<0.05).After treatment,the levels of bifidobacterium,Lactobacillus and eubacillus in the observation group were(10.65±0.63)×10^(8) CFU/mL,(9.49±0.48)×10^(8) CFU/mL,and(8.91±0.71)×10^(8) CFU/mL,respectively.They were higher than those in control group(9.68±0.49)×10^(8) CFU/mL,(9.06±0.56)×10^(8) CFU/mL,(8.13±0.52)×10^(8) CFU/mL(P<0.05).After treatment,the levels of immunoglobulin M(IgM),immunoglobulin G(IgG)and immunoglobulin A(IgA)in the observation group were(2.19±0.33)g/L,(11.59±1.50)g/L and(1.69±0.36)g/L,respectively.They were higher than those in the control group(1.79±0.30)g/L,(9.46±1.10)g/L and(1.40±0.33)g/L(P<0.05).Conclusions Probiotics combined with montmorillonite powder can effectively inhibit inflammatory response,maintain intestinal flora balance,and improve immune function in the treatment of children with ADD,which has clinical promotion value.
作者
翟德菊
张淑华
王慧
邓梦珂
ZHAI Deju;ZHANG Shuhua;WANG Hui(Zhengzhou Third People′s Hospital,Henan Zhengzhou 450000)
出处
《航空航天医学杂志》
2023年第12期1415-1418,共4页
Journal of Aerospace medicine
关键词
抗生素相关腹泻
肠道菌群
免疫功能
益生菌
炎性因子
Antibiotic related diarrhea
Intestinal flora
Immune function
Probiotics
Inflamma⁃tory factor
