摘要
目的 探究复方嗜酸乳杆菌片联合马来酸曲美布汀治疗腹泻型肠易激综合征患者的效果。方法 选取103例腹泻型肠易激综合征患者作为研究对象,随机将其分为对照组(51例)和观察组(52例)。对照组行马来酸曲美布汀片治疗,观察组在对照组基础上行复方嗜酸乳杆菌片治疗。比较两组患者临床疗效,腹痛、腹泻评分,胃肠相关激素水平,以及肠道菌群数量和不良反应发生情况。结果 治疗1个月后,观察组治疗总有效率、乳杆菌菌群数量均高于对照组,腹痛评分、腹泻评分、5-羟色胺水平、神经肽Y水平、生长抑素水平、肠球菌菌群数量、酵母样真菌菌群数量均低于对照组(均P<0.05)。两组不良反应发生情况差异无统计学意义(P>0.05)。结论 复方嗜酸乳杆菌联合马来酸曲美布汀可以有效地改善腹泻型肠易激综合征患者的症状,调节胃肠相关激素,促进肠道菌群平衡,安全性较高。
Objective To investigate the effect of compound Lactobacllus acidophilus tablets combined with trimetbutine maleate in the treatment of patients with irritable bowel syndrome with diarrhea.Methods A total of 103 patients with irritable bowel syndrome with diarrhea were selected as research subjects and randomly divided into a control group(51 cases)or an observation group(52 cases).The control group was treated with trimebutine maleate tablets,based on which the observation group was treated with compound Lactobacillus acidophilus tablets.The clinical efficacy,abdominal pain and diarrhea scores,gastrointestinal hormones levels,intestinal flora numbers,and incidence of adverse reactions were compared between the two groups.Results After 1 month of treatment,the total effective rate of treatment and the lactobacilus number in the observation group were higher than those in the control group,and the abdominal pain and diarrhea scores,5-hydroxytryptamin level,neuropeptide Y level,somatostatin level,enterococcus number,and yeast-like fungi number in the observation group were lower than those in the control group(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compound Lactobacilus acidophilus combined with trimebutine maleate can effectively improve the symptoms of patients with irritable bowel syndrome with diarrhea,regulate gastrointestinal hormones,promote the balance of intestinal flora,and with high safety.
作者
耿红芳
靳永辉
黄琮超
于泳
欧阳旺甫
GENG Hongfang;JIN Yonghui;HUANG Congchao;YU Yong;OUYANG Wangfu(Department of Gastroenterology,the People's Hospital of Hebi,Hebi 458030,Henan Province,China;Department of Nuclear Medicine,the People's Hospital of Hebi,Hebi 458030,Henan Province,China;Department of Internal Medicine,the People's Hospital of Hebi,Hebi 458030,Henan Province,China;Department of Internal Medicine,Sanquan College,Xinxiang Medical College,Xinxiang 453003,Henan Province,China)
出处
《内科》
2023年第6期557-560,共4页
Internal Medicine
关键词
复方嗜酸乳杆菌片
腹泻型肠易激综合征
5-羟色胺
神经肽Y
生长抑素
Compound Lactobacilus acidophilus tablets
Irritable bowel syndrome with diarrhea
5-hydroxytryptamin
Neuropeptide Y
Somatostatin
