摘要
目的揭示较常出现血瘀证的疾病异病同治的规律特征,为血瘀证临床治疗与新药开发提供依据。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(重庆维普)、中国学术期刊数据库(万方数据)、中国生物医学文献服务系统(SinoMed)、中华医学期刊全文数据库自建库至2022年12月31日的血瘀证临床研究RCT文献,提取疾病、兼证、处方及药物,选取出现频次较高的3个患病系统中频次最高的疾病,结合频次统计及关联规则Apriori算法分析其用药特点及处方规律,挖掘3类疾病血瘀证核心处方,并进行网络相似性分析。结果共纳入文献2052篇,稳定性冠心病、缺血性卒中、DN为较常出现血瘀证的疾病。3种疾病共同用药为川芎、红花、桃仁、当归。稳定性冠心病核心处方为桃红-红花-川芎-当归-赤芍;缺血性卒中核心处方为补阳还五汤;DN核心处方为桃红-红花-川芎-当归-山萸肉-山药-黄芪。稳定性冠心病与缺血性卒中核心处方网络相似度为0.35,缺血性卒中与DN核心处方网络相似度为0.29,稳定性冠心病与DN核心处方网络相似度为0.26。结论“异病同治”理论深刻指导临床实践。血瘀证核心药物为桃仁、红花、当归、川芎,在此基础上结合不同疾病与兼证加减变化。
Objective To reveal the regular pattern characteristics of different diseases with the same treatment in the most common diseases with blood stasis syndrome;To provide reference for the clinical treatment of blood stasis syndrome and the development of new drugs.Methods RCTs of blood stasis syndrome were retrieved from CNKI,Chongqing VIP,Wanfang Data,SinoMed,and China Medical Journal Full-text Database from the establishment of the databases to December 31,2022.Diseases,accompanied symptoms,prescriptions and medicines were extracted.The diseases with the highest frequency among the three disease systems with the highest frequency were collected,and their medication characteristics and prescription rules were analyzed using frequency statistics and association rules Apriori algorithm.The core prescriptions of blood stasis syndrome of three kinds of diseases were excavated and their network similarity was analyzed.Results A total of 2052 articles were included.Stable coronary heart disease,ischemic stroke and DN were more common diseases with blood stasis syndrome.The common drugs for the three diseases were Chuanxiong Rhizoma,Carthami Flos,Persicae Semen,Angelicae Sinensis Radix.The core prescription of stable coronary heart disease was Persicae Semen-Carthami Flos-Chuanxiong Rhizoma-Angelicae Sinensis Radix-Paeoniae Radix Rubra;the core prescription of ischemic stroke is Buyang Huanwu Decoction;the core prescription of DN was Persicae Semen-Carthami Flos-Chuanxiong Rhizoma-Angelicae Sinensis Radix-Cornus Officinalis-Dioscoreae Rhizoma-Astragali Radix.The similarity between stable coronary heart disease and ischemic stroke core prescription network was 0.35,the similarity between ischemic stroke and DN core prescription network was 0.29,and the similarity between stable coronary heart disease and DN core prescription network was 0.26.Conclusions The theory of"different diseases with the same treatment"can profoundly guide clinical practice.The core medicines of blood stasis syndrome are Persicae Semen,Carthami Flo
作者
冷媛媛
宋祺
王念
顾浩
刘骏
王忠
Yuanyuan Leng;Qi Song;Nian Wang;Hao Gu;Jun Liu;Zhong Wang(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Research and Education Division,Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Clinical Pharmacology Laboratory of Traditional Chinese Medicine,Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《国际中医中药杂志》
2023年第6期760-765,共6页
International Journal of Traditional Chinese Medicine
基金
中国中医科学院科技创新工程项目(CI2021A05033)。
关键词
异病同治
血瘀证
数据挖掘
关联规则
网络相似性
Treating different diseases with same method
Xueyu Zheng(Blood stasis syndrome)
Data mining
Association rules
Network similarity
