摘要
目的探讨缺血性脑卒中患者中医证候特征及其与中医体质的相关性。方法采用多中心、前瞻性的注册登记式研究,收集2016年7月至2019年11月全国7家分中心的缺血性脑卒中患者的资料,包括患者的性别、年龄、体重指数(BMI)、基础疾病、病程等一般资料,诊断信息、发病情况等临床资料。由经过系统培训的各参研单位的临床医生进行中医证候和体质判定,将缺血性脑卒中分为风痰火亢证、风火上扰证、痰热腑实证、阴虚风动证、风痰瘀阻证、痰湿蒙神证、气虚血瘀证7个证型,体质分为阳虚质、阴虚质、气虚质、痰湿质、湿热质、血瘀质、气郁质、特禀质、平和质9种体质。采用典型相关分析的方法分析中医证型与中医体质之间的关系。结果共纳入患者2558例,中医证型以气虚血瘀证(1506例,58.87%)、风痰瘀阻证(1166例,45.58%)为主,体质以平和质(632例,24.71%)、气虚质(561例,21.93%)、血瘀质(531例,20.76%)、痰湿质(370例,14.46%)为主。相关分析表明,气虚血瘀证与气虚质、血瘀质、阳虚质呈显著相关,风痰瘀阻证与痰湿质、阳虚质显著相关,风火上扰证、阴虚风动证与阴虚质显著相关,风痰火亢证、痰湿蒙神证与痰湿质呈显著相关,风火上扰证、痰热腑实证与湿热质呈显著相关(P<0.05或P<0.01)。结论缺血性脑卒中患者的常见证候类型为气虚血瘀证与风痰瘀阻证,常见体质类型包括平和质、气虚质、血瘀质和痰湿质,缺血性脑卒中患者的中医证候与中医体质密切相关。
Objective To explore the characteristics of traditional Chinese medicine(TCM)syndromes and its correlation with TCM constitutions in patients with ischemic stroke(IS).Methods A multi-center,prospective registration study was conducted;data on IS patients from seven centers across the country from July 2016 to November 2019 were collected,including gender,age,body mass index(BMI),basic disease,course of disease and other general information,as well as diagnosis information,disease situation and other clinical data.Systematically trained clinicians of each participating center determined the TCM syndrome and constitution of each patient.TCM syndromes of IS patients were classified into seven major types,which were wind-phlegm fire hyperactivity syndrome,wind-fire harassing the upper body syndrome,phlegm-heat and bowel excess syndrome,yin deficiency and stirring of wind syndrome,wind-phlegm stasis and constraint syndrome,phlegm-damp confusing the mind syndrome,qi deficiency and blood stasis syndrome.Nine constitution types were involved,including yang deficiency constitution,yin deficiency constitution,qi deficiency constitution,phlegm-damp constitution,damp-heat constitution,blood stasis constitution,qi constraint constitution,inherited special constitution and balanced constitution.The canonical correlation analysis was performed to analyze the correlation between TCM syndromes and constitutions.Results A total of 2558 patients were included,who were mainly of qi deficiency and blood stasis syndrome(1,506 cases,58.87%)and wind-phlegm stasis and constraint syndrome(1,166 cases,45.58%);the major constitutions were balanced constitution(632 cases,24.71%),qi deficiency constitution(561 cases,21.93%),blood stasis constitution(531 cases,20.76%),and phlegm-damp constitution(370 cases,14.46%).Correlation analysis showed that qi deficiency and blood stasis syndrome was significantly correlated to constitutions of qi deficiency,blood stasis and yang deficiency;the wind-phlegm stasis and constraint syndrome was significantly
作者
张利丹
谢雁鸣
高阳
魏瑞丽
ZHANG Lidan;XIE Yanming;GAO Yang;WEI Ruili(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing,100700)
出处
《中医杂志》
CSCD
北大核心
2021年第16期1416-1420,共5页
Journal of Traditional Chinese Medicine
基金
中医药行业科研专项(201507003-8)。
关键词
缺血性脑卒中
中医证候
中医体质
典型相关分析
ischemic stroke
traditional Chinese medicine syndromes
traditional Chinese medicine constitution
canonical correlation analysis
