摘要
目的:观察自拟养血安神汤治疗心脾两虚型失眠症的临床疗效。方法:选取2019年10月至2021年10月天津市和平区五大道街社区卫生服务中心治疗的心脾两虚型失眠症患者120例,按照随机数字表法分为观察组和对照组,每组60例。对照组给予艾司唑仑片治疗,观察组给予养血安神汤治疗。观察两组患者治疗前后睡眠质量[兹堡睡眠质量指数(Pittsburgh Sleep Quality Index, PSQI)、Epworth困倦量表(Epworth sleepiness score, ESS)评分]、中医证候积分、焦虑症状积分[焦虑症状自评量表(self-rating anxiety scale, SAS)评分、汉密尔顿焦虑量表(hamilton anxiety scal, HAMA)评分]、神经递质表达水平[促甲状腺激素(thyroid-stimulating hormone, TSH)、皮质醇(Cortisol, Cor)、生长激素(growth hormone, GH)、游离甲状腺素(free thyroxine 4,FT4)]及临床疗效。结果:观察组有效率为96.7%,对照组有效率为83.3%,观察组有效率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后PSQI评分、ESS评分、中医证候积分、SAS评分、HAMA评分、TSH、GH、Cor、FT4均低于治疗前,且观察组PSQI评分、ESS评分、中医证候积分、焦虑评分、SAS评分、HAMA评分、TSH、GH、Cor、FT4均低于对照组,差异有统计学意义(P<0.05)。结论:自拟养血安神汤治疗心脾两虚型失眠症,可改善患者睡眠质量、焦虑症状、中医证候,其改善作用可能与调节神经递质TSH、GH、Cor、FT4的表达有关。
Objective: To observe the clinical efficacy of self-made Blood-Nourishing Tranquilizering Decoction on insomnia with deficiency of both heart and spleen.Methods: A total of 120 patients with deficiency of both heart and spleen type who were treated in Wudaojie Street Community Health Service Center of Heping District of Tianjin from October 2019 to October 2021 were selected and divided into the observation group and the control group according to random number table, with 60 cases in each group.Then the changes of sleep quality [including Pittsburgh Sleep Quality Index(PSQI),Epworth sleepiness score(ESS) score],TCM syndrome score, anxiety symptom score [including self-rating anxiety scale(SAS) score, Hamilton anxiety scale(HAMA) score],the expression levels of neurotransmitters [thyroid stimulating hormone(TSH),cortisol(Cor),growth hormone(GH),free thyroxine 4(FT4)] and clinical efficacy before and after treatment were observed.Results: The effective rate was 96.7% in the observation group and 83.3% in the control group.The effective rate in the observation group was higher than that in the control group, with a statistically significant difference(P<0.05).After treatment, the PSQI score, ESS score, TCM syndrome score, SAS score, HAMA score, TSH,GH,Cor, FT4 of the two groups were lower than those before treatment, and the PSQI score, ESS score, TCM syndrome score, anxiety score, SAS score, HAMA score, TSH,GH,Cor, FT4 of the observation group were lower than those of the control group, with statistical differences(P<0.05).Conclusion: Self-made Blood-Nourishing Tranquilizering Decoction can improve the sleep quality, anxiety symptoms and TCM syndromes of patients with insomnia of the deficiency of both heart and spleen, which may be related to regulating the expressions of neurotransmitters TSH,GH,Cor and FT4.
作者
罗希
葛立君
LUO Xi;GE Li-jun(Wudadaojie Street Community Health Sen'ice Center of Hoping District of Tianjin,Tianjin,China,300050;Hoping District Hospital of Traditional Chinese Medicine of Tianjin,Tianjin,China,300050)
出处
《河南中医》
2023年第2期253-256,共4页
Henan Traditional Chinese Medicine
基金
天津市中医药管理局中西医结合科研课题项目(2019039)。
关键词
失眠症
心脾两虚证
养血安神汤
艾司唑仑片
insomnia
deficiency of both heart and spleen
Blood-Nourishing Tranquilizering Decoction
Estazolam Tablets
