摘要
目的研究血清维生素D水平与幽门螺杆菌根除率的关系,为提高幽门螺杆菌的临床根除率提供用药参考。方法选取156例幽门螺杆菌阳性患者作为阳性组,另选取同期156例幽门螺杆菌阴性患者作为阴性组,均进行血清维生素D测定,比较阴性组和阳性组血清维生素D水平;阳性组患者以血清维生素D水平分为≤10 ng/ml组(69例)和>10 ng/ml组(87例),均给予传统14 d铋剂四联疗法治疗,比较≤10 ng/ml组和>10 ng/ml组的幽门螺杆菌根除率、不良反应发生情况。结果阳性组患者血清维生素D为(5.12±0.16)ng/ml,明显低于阴性组的(26.71±0.27)ng/ml,差异具有统计学意义(t=859.2051,P<0.05)。≤10 ng/ml组幽门螺杆菌根除率为57.97%,明显低于>10 ng/ml组的82.76%,差异有统计学意义(χ2=11.6759,P<0.05)。阳性组和阴性组均无明显不良反应发生,仅有1例出现轻微的恶心情况。结论感染幽门螺杆菌患者血清维生素D水平较低,且血清维生素D水平越低,幽门螺杆菌根除率越低。
Objective To study the correlation between serum vitamin D level and Helicobacter pylori eradication rate,so as to provide reference for the improvement of clinical eradication rate of Helicobacter pylori.Methods 156 Helicobacter pylori-positive patients were taken as the positive group,and 156 Helicobacter pylori-negative patients during the same period were taken as the negative group.Serum vitamin D was measured,and the levels of serum vitamin D were compared between the negative group and the positive group.Patients in the positive group were divided into≤10 ng/ml group(69 cases)and>10 ng/ml group(87 cases)according to serum vitamin D level,and all were given traditional 14 d bismuth quadruple therapy to compare the eradication rate of Helicobacter pylori and the occurrence of adverse reactions between the≤10 ng/ml group and>10 ng/ml group.Results The serum vitamin D level in the positive group was(5.12±0.16)ng/ml,which was significantly lower than(26.71±0.27)ng/ml in the negative group,and the difference was statistically significant(t=859.2051,P<0.05).The eradication rate of Helicobacter pylori in the≤10 ng/ml group was 57.97%,which was significantly lower than 82.76%in the>10 ng/ml group,and the difference was statistically significant(χ2=11.6759,P<0.05).No significant adverse reactions occurred in the positive group and negative group,and only 1 case of mild nausea was observed.Conclusion Patients infected with Helicobacter pylori have lower serum vitamin D levels,and the lower the serum vitamin D level,the lower the Helicobacter pylori eradication rate.
作者
赵炳超
ZHAO Bing-chao(Department of Gastroenterology,Yantai Laiyang Central Hospital,Yantai 265200,China)
出处
《中国实用医药》
2022年第16期53-55,共3页
China Practical Medicine
基金
烟台市重点研发计划政策引导类项目(项目编号:2021YD091)项目名称:维生素D制剂在提高幽门螺旋杆菌根除率中的相关研究。
关键词
维生素D
幽门螺杆菌
铋剂四联疗法
Vitamin D
Helicobacter pylori
Bismuth quadruple therapy
