摘要
炎症性肠病(inflammatory bowel disease,I B D)是由环境、遗传和免疫因素共同参与所导致的复杂的慢性炎性疾病,炎症性肠病的病因和发病机制至今仍未明确.近年来,有越来越多致力于研究维生素D的学者逐渐将目光由传统骨代谢疾病转向免疫系统相关疾病(如IBD),维生素D除参与钙、磷代谢外,还可通过调节机体免疫细胞因子,诱导表达抗菌肽以及维持肠黏膜屏障的完整性,缓解炎症性肠病的疾病程度.鉴于维生素D的抗感染和免疫调节作用,本文就维生素D在炎症性肠病中的相关作用机制做一初步探讨.
Inflammatory bowel disease （IBD） is a complex chronic inflammatory disorder caused by the interaction of environmental, hereditary and immune factors. The etiology and pathogenesis of IBD remain unveiled. In recent years, growing attention has been paid to the role of vitamin D in immune-related diseases like IBD from traditional bone metabolism. Vitamin D not only participates in calcium and phosphorus metabolism but also alleviates IBD via regulating the immune cell factors, inducing antimicrobial peptide expression and maintaining the integrity of intestinal mucosal barrier. In view of anti-inflammatory and immunomodulatory activities of vitamin D, this article discusses its role in IBD.
出处
《世界华人消化杂志》
CAS
2015年第35期5655-5661,共7页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81303033
上海市卫生系统优秀学科带头人计划资助项目
No.XBR2013106
新世纪优秀人才支持计划资助项目
No.NCET-13-0907
国家973计划项目资助项目
No.2015CB554500~~
关键词
炎症性肠病
维生素D
免疫调节
抗感染
黏膜屏障
Inflammatory bowel disease
VitaminD
Immune regulation
Anti-inflammatory
lucosalbarrier
