摘要
目的:分析根除幽门螺旋杆菌治疗失败的原因及其临床影响因素。方法:选取幽门螺旋杆菌感染病人257例,按照幽门螺旋杆菌根除结果分为失败组77例和治愈组180例,收集病人一般资料及临床相关指标,分析根除幽门螺旋杆菌治疗失败的原因。结果:幽门螺旋杆菌根除失败率为29.96%(77/257)。单因素分析显示,居住地、文化程度、有家庭成员感染、CagA阳性、口腔HP感染、治疗情况、不规则服药、耐药、未全程督导在失败组和治愈组之间差异均有统计学意义(P<0.05~P<0.01)。logistic回归分析显示,文化程度和不规则服药均为根除失败的独立影响因素(P<0.01和P<0.05)。结论:文化程度、不规则服药等多种因素影响根除幽门螺旋杆菌治疗结果,临床应根据相关影响因素及早干预。
Objective:To analyze the reason of the eradication failure of Helicobacter pylori(HP),and its clinical influencing factors.Methods:Two hundred and fifty-seven patients with HP infection were divided into the failure group(77 cases) and cure group(180 cases) according to the eradicating result.The general information and clinical indicators in two groups were collected to analyze the failure causes of eradicating HP.Results:The failure rate of eradicating HP was 29.96%(77/227).The results of univariate analysis showed that the differences of the residence,education level,infection of family members,CagA positive,oral HP infection,treatment status,irregular medication,drug resistance and incomplete supervision between two groups were statistically significant(P<0.05 to P<0.01).The results of logistic regression analysis showed that the education level and irregular medication were the independent influencing factors of eradication failure(P<0.01 and P<0.05).Conclusions:A variety of factors,such as cultural level and irregular medication,can affect the eradication results of HP,and the clinical intervention should be conducted as early as possible according to relevant influencing factors.
作者
袁龙良
辛毅
王启之
YUAN Long-liang;XIN Yi;WANG Qi-zhi(Department of Gastroenterology,Suzhou Municipal Hospital,Suzhou Anhui 234000;Department of Gastroenterology,The first Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)
出处
《蚌埠医学院学报》
CAS
2019年第11期1497-1499,共3页
Journal of Bengbu Medical College
关键词
幽门螺旋杆菌
感染
根除治疗
Helicobacter pylori
infection
eradication therapy
