摘要
目的探讨甲硝唑凝胶联合多西环素治疗玫瑰痤疮的效果和对患者症状积分的影响。方法选取2020年1月至7月常州市疾病预防控制中心收治的91例玫瑰痤疮患者作为研究对象,采用随机数字表法将其分为对照组(n=45)和观察组(n=46)。对照组患者采用多西环素治疗,观察组患者采用甲硝唑凝胶联合多西环素治疗。比较两组患者的临床疗效、治疗前后皮肤状态和症状积分,另外比较两组的药物不良反应发生情况。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗前,两组患者的皮肤状态和症状积分比较,差异无统计学意义(P>0.05);观察组患者治疗后的角质层含水量高于对照组,pH值、经皮水分丢失量、皮肤红斑指数、瘙痒评分、丘疹脓疱评分和红斑评分低于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论在玫瑰痤疮患者的治疗中实施甲硝唑凝胶联合多西环素方案,效果明显,对皮肤状态和临床症状改善作用明显,不增加药物不良反应,有推广价值。
Objective To investigate the effect of Metronidazole Gel combined with Doxycycline in the treatment of rosacea and its influence on the patients′symptom scores.Methods A total of 91 patients with rosacea who were admitted to Changzhou Center for Disease Control and Prevention from January to July 2020 were selected as subjects and divided into a control group(n=45)and an observation group(n=46)by random number table method.The patients in the control group were treated with Doxycycline,and the patients in the observation group were treated with Metronidazole Gel combined with Doxycycline.The clinical efficacy,skin condition and symptom scores before and after treatment were compared between the two groups.In addition,the adverse drug reactions were compared between the two groups.Results The total effectiveness rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistical differences in the skin condition and symptoms scores between the two groups(P>0.05).After treatment,the water content of the stratum corneum in the observation group was higher than that of the control group,and the pH value,transepidermal water loss,skin erythema index,pruritus score,papule-pustule score,and erythema score in the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Metronidazole Gel combined with Doxycycline is effective in the treatment of patients with rosacea,and it has obvious effect on improving skin condition and clinical symptoms,and will not result in the adverse drug reactions.It has promotion value.
作者
方兴
FANG Xing(Changzhou Center for Disease Control and Prevention,Jiangsu Province,Changzhou213003,China)
出处
《中国当代医药》
CAS
2022年第22期50-53,共4页
China Modern Medicine
