摘要
目的:探讨超脉冲CO_(2)点阵激光对光老化患者皮肤特征评分及皮肤屏障功能的影响。方法:选取我院2018年7月至2020年7月收治的皮肤光老化患者183例为研究对象,采用非随机同期对照法将患者分为超脉冲组(n=102)与Er:YAG激光组(n=81)。超脉冲组患者予以超脉冲CO_(2)点阵激光治疗,Er:YAG激光组予以Er:YAG点阵激光治疗。治疗6个月后,比较两组患者治疗前、治疗后3个月皮肤特征评分(VISIA皮肤图像分析)、皮肤屏障功能[经皮水分丢失(TEwL)、皮肤表面pH值、角质层含水量、皮肤油脂含量]、改善程度[整体美学改善评分(GAIS)、光老化整体评分(GSP)]水平,对比两组患者治疗6个月期间不良反应发生情况及治疗后3个月满意度自评分。结果:治疗前,两组患者皮肤特征评分、皮肤屏障功能、改善程度水平比较差异无统计学意义;超脉冲组患者皮肤斑点、纹理、红质、紫质、紫外线色斑得分、TEwL、皮肤表面pH值、角质层含水量、皮肤油脂含量、GAIS、GSP得分治疗前后差值显著高于Er:YAG激光组(P均<0.05);超脉冲组患者总满意度显著高于Er:YAG激光组(P<0.05)。治疗6个月内,两组患者不良反应发生情况(疼痛、红斑、瘢痕增生、色素沉着)差异无统计学意义(P均>0.05)。结论:使用超脉冲CO_(2)点阵激光治疗皮肤光老化疗效确切,可以有效改善患者皮肤状态、修复皮肤屏障,具有较高的临床应用价值。
Objective:To investigate the effects of ultra-pulse CO_(2) fractional laser on skin characteristics scores and skin barrier function in patients with photoaging.Methods:A total of 183 patients with skin photoaging admitted to the hospital between July 2018 and July 2020 were selected as the research subjects.The patients were divided into ultra-pulse group(n=102)and Er:YAG laser group(n=81)according to the non-randomized and concurrently controlled method.The patients in the ultra-pulse group received ultra-pulse CO_(2) fractional laser treatment,and the Er:YAG laser group was given Er:YAG fractional laser treatment.After 6 months of treatment,the skin characteristics scores(VISIA skin image analysis),skin barrier function[transepidermal water loss(TEwL),skin surface pH value,water content of stratum corneum,skin grease content]and level of improvement[Global Aesthetic Improvement Scale(GAIS),Global Score for Photoaging(GSP)]were compared between the two groups before treatment and at 3 months after treatment.The occurrence of adverse reactions during 6 months of treatment and satisfaction self-rating score at 3 months after treatment were compared between the two groups.Results:Before treatment,there were no statistical differences in skin characteristics scores,skin barrier function and improvement level between the two groups.The differences of scores of skin spots,texture,pores,red matter,purple matter and ultraviolet spots,TEwL,skin surface pH value,water content of stratum corneum,skin grease content,GAIS score and GSP score before and after treatment were significantly higher in ultra-pulse group than those in Er:YAG laser group(all P<0.05).The total satisfaction of patients in ultra-pulse group was significantly higher compared to Er:YAG laser group(P<0.05).Within 6 months of treatment,the differences in the occurrence of adverse reactions(pain,erythema,scar hypertrophy,hyperpigmentation)were not statistically significant between the two groups(all P>0.05).Conclusion:Ultra-pulse CO_(2) fractional laser ha
作者
王欢欢
严晓雪
WANG Huanhuan;YAN Xiaoxue(The First Affiliated Hospital of Air Force Military Medical University,Shaanxi Xi'an 710032,China)
出处
《河北医学》
CAS
2022年第7期1199-1205,共7页
Hebei Medicine
基金
国家自然科学基金项目,(编号:8157101513)。