摘要
目的 研究癫痫持续状态(SE)患儿血清载脂蛋白A2(APOA2)、免疫球蛋白A(IgA)与腺苷脱氨酶(ADA)的表达及临床意义。方法 纳入青海省妇女儿童医院2018-01—2020-10收治的87例SE患儿以及50例健康同龄儿童为研究对象,根据发作类型[(全身惊厥持续状态(GCSE)与非惊厥性持续状态(NCSE)]、病因(症状性、原发性)、SE持续时间(持续时间≤60 min、>60 min)、控制时间(≤30 min、>30min)以及远期预后情况(死亡组、后遗症、预后良好)进行分组,分别比较各亚组血清APOA2、IgA以及ADA水平,分析以上指标与SE患儿临床特征之间的关系。结果 SE患儿血清APOA2水平低于健康组[(0.23±0.05)g/L vs(0.33±0.07)g/L],ADA水平高于健康组[(13.55±2.67)U/L vs(5.69±1.49)U/L],差异有统计学意义(P<0.05),2组血清IgA水平比较差异无统计学意义(P>0.05)。GCSE及NCSE患儿血清APOA2、IgA以及ADA水平比较,差异无统计学意义(P>0.05)。原发性SE患儿血清IgA水平低于症状性SE患儿[(2.11±0.51)g/L vs(2.45±0.63)g/L],差异有统计学意义(P<0.05),2组血清APOA2水平以及ADA活性比较差异无统计学意义(P>0.05)。发作持续时间>60 min患儿血清APOA2及IgA水平均低于发作持续时间≤60 min患儿[(0.20±0.048)g/L vs(0.26±0.08)g/L,(2.28±0.25)g/L vs(2.46±0.34)g/L],ADA水平高于发作持续时间≤60 min组[(15.51±3.11)U/L vs(12.03±2.89)U/L],差异均有统计学意义(P<0.05)。控制时间>30 min患儿组血清APOA2[(0.19±0.04)g/L vs(0.25±0.07)g/L]及IgA[(2.16±0.41)g/L vs(2.48±0.63)g/L]水平均低于控制时间≤30 min患儿组,ADA水平[(15.81±3.02)U/L vs(12.53±2.46)U/L]高于控制时间≤30 minn患儿组,差异有统计学意义(P<0.05)。死亡组、后遗症组、预后良好组间血清APOA2[(0.11±0.02)g/L vs(0.14±0.03)g/L vs(0.28±0.08)g/L]、IgA[(1.86±0.39)g/L vs(2.13±0.46)g/L vs(2.55±0.51)g/L]以及ADA[(23.54±2.68)U/L vs(17.34±3.14)U/L vs(10.69±2.11)U/L]水平比较,差异有统计学意义(P<0.05),其中预后良�
Objective To analyze the expression and significance of serum apolipoprotein A2(APOA2),immunoglobulin A(IGA) and adenosine deaminase(ADA) in children with status epilepticus(SE).Methods Eighty-seven SE children and another 50 healthy children in Qinghai Women’ s and Children’ s Hospital from January 2018 to October 2020 were enrolled.SE children were classified into groups in terms of the seizure type(generalized convulsive status epilepticus(GCSE) versus non convulsive status epilepticus(NCSE)),etiology(symptomatic type versus primary type),duration of SE(≤60 min versus>60 min),duration of control(≤30 min versus> 30 min),and long-term prognosis(death,sequelae,good prognosis).Serum APOA2,IgA and ADA levels of children in each subgroup were compared,then the relationship between above indicators and clinical characteristics of children with SE was discussed.Results Compared with healthy control group,SE children had a decrease in serum APOA2 level,and an increase in ADA activity,with statistical difference((0.23±0.05) g/L vs(0.33±0.07) g/L,(13.55±2.67) U/L vs(5.69±1.49) U/L,all P<0.05),while serum IgA level yielded no statistical difference between healthy controls and SE children(P>0.05).No significant difference was found in serum APOA2,IgA levels and ADA activity between GCSE children and NCSE children(P>0.05).Serum IgA level of primary SE was higher than that of symptomatic SE,with statistical difference((2.11±0.51) g/L vs(2.45±0.63) g/L,P<0.05),while no statistical difference was found in serum APOA2 levels and ADA activity between symptomatic and primary SE children(P>0.05).Serum APOA2 and IgA levels in children with seizure duration>60 min were lower than those in children with seizure duration-60 min((0.20±0.048) g/L vs(0.26±0.08) g/L,(2.28±0.25) g/L vs(2.46±0.34) g/L),and ADA activity was greater than that with seizure duration>60 min((15.51±3.11) U/L vs(12.03±2.89) U/L),with statistical differences(all P<0.05).Serum APOA2 and IgA levels in children with control time>30 minutes were lo
作者
韩玉娟
邓劼
HAN Yujuan;DENG Jie(Qinghai Women’s and Children’s Hospital,Xining 810000,China;Beijing Children’s Hospital,Beijing 100045,China)
出处
《中国实用神经疾病杂志》
2022年第5期603-608,共6页
Chinese Journal of Practical Nervous Diseases
基金
青海省科技计划项目(编号:2019-ZJ-T06)。
