摘要
目的观察不同抗癫痫药物治疗前后患儿血清免疫球蛋白水平的变化。方法选取2020年6月-2022年3月江门市中心医院儿科收治的57例特发性癫痫患儿,根据患者不同发作类型将治疗组分为:①丙戊酸钠治疗组30例(全面性发作);②奥卡西平治疗组12例(局灶性发作);③吡仑帕奈治疗组15例(局灶性发作),选取同期在门诊进行健康检查的69例儿童作为对照组;对各组儿童血清免疫球蛋白IgG、IgM、IgA进行测定,检测各治疗组儿童用药前、用药6个月后的血清免疫球蛋白IgG、IgM、IgA水平,并与对照组进行比较,分析不同用药组用药前后血清免疫球蛋白水平的变化。结果丙戊酸钠组(全面性发作)治疗前体液免疫功能受损,与对照组相比,血清免疫球蛋白IgA、IgG水平明显下降,治疗后血清免疫球蛋白IgG较用药前明显升高,IgM较用药前明显下降,差异有统计学意义(P<0.001);血清免疫球蛋白IgA水平无明显变化(P>0.05)。奥卡西平组、吡仑帕奈组(局灶性发作)治疗前血清免疫球蛋白IgG、IgM、IgA水平与对照组相比无明显变化,治疗后血清免疫球蛋白IgG、IgM、IgA水平与治疗前相比无明显变化,差异无统计学意义(P>0.05)。结论癫痫患儿治疗前存在体液免疫功能受损,尤其在全面性发作患儿当中表现明显,在局灶性发作患儿中不明显;丙戊酸钠有明显免疫调节作用,奥卡西平、吡仑帕奈则无免疫调节作用。
Objective To observe the changes in serum immunoglobulin levels in children before and after treatment with different antiepileptic drugs.Methods 57 children with idiopathic epilepsy admitted to the pediatrics department of Jiangmen Central Hospital from June 2020 to March 2022 were selected.According to different types of seizures in patients,treatment group were divided into①valproate sodium treatment group with 30 cases(generalized seizures);②oxcarbazepine treatment group with 12 cases(focal seizures);③perampanel treatment group with 15 cases(focal seizures).At the same time,69 children who underwent health check ups in the outpatient department during the same period were selected as control group.The serum immunoglobulin IgG,IgM and IgA levels in each group were measured,and the serum immunoglobulin IgG,IgM and IgA levels in each treatment group were tested and compared with those of the control group to analyze the changes of serum immunoglobulin levels before and after medication in different treatment groups.Results The sodium valproate group(generalized seizures)had impaired humoral immune functions before treatment,compared with the control group,the levels of serum immunoglobulin IgA and IgG decreased significantly.After treatment,the levels of serum immunoglobulin IgG increased significantly and IgM decreased significantly compared to those before medication,and difference was statistically significant(P<0.001);but there was no significant change in serum immunoglobulin IgA levels(P>0.05).Before treatment,the serum levels of immunoglobulins IgG,IgM,and IgA in the oxcarbazepine group and perampanel group(focal seizures)showed no significant changes compared to those in the control group.After treatment,the serum levels of immunoglobulins IgG,IgM,and IgA showed no significant changes compared to those before treatment,and difference was not statistically significant(P>0.05).Conclusion Before treatment,humoral immune functions are impaired in children with epilepsy,especially in children with gener
作者
郭梦杰
吕冰聪
郭青云
赵海丰
GUO Mengjie;LYU Bingcong;GUO Qingyun;ZHAO Haifeng(Department of Pediatrics,Jiangmen Central Hospital,Jiangmen 529000,Guangdong,China)
出处
《右江医学》
2024年第8期707-711,共5页
Chinese Youjiang Medical Journal
基金
江门市科技计划项目(2020020301420003445)。
关键词
癫痫
抗癫痫药物
免疫球蛋白
儿童
epilepsy
antiepileptic drugs
immunoglobulin
children
