摘要
目的:观察涤痰汤治疗痰浊阻窍型强直-阵孪性发作癫痫患儿的临床疗效及对癫痫患儿免疫球蛋白、外周血辅助性T细胞17(Th17),白细胞介素-6(IL-6),白细胞介素-17A(IL-17A)的影响。方法:将100例患儿按随机数字表法产生的随机分配序列放入密封的信封中,按顺序拆开信封并将受试对象分配入相应的对照组和观察组。对照组给予丙戊酸钠口服溶液治疗,观察组在对照组的基础上给予涤痰汤治疗。总疗程3个月,检测治疗前后两组患儿免疫球蛋白M(IgM),免疫球蛋白A(IgA),免疫球蛋白G(IgG)及Th17,IL-6,IL-17A,C-反应蛋白(hs-CRP),血同型半胱氨酸(Hcy)的变化,不良反应发生情况。比较两组患儿治疗前和治疗后3个月,癫痫发作次数、发作持续时间、脑电图的变化。结果:涤痰汤联合丙戊酸钠治疗痰浊阻窍型强直-阵孪发作癫痫患儿3个月后,观察组临床总有效率优于对照组(P<0.05)。治疗后,观察组在癫痫计分减少上面均优于对照组(P<0.05)。与本组治疗前比较,观察组IgG,IgA水平升高(P<0.05),外周血Th17,IL-6,IL-17A,hs-CRP,Hcy水平下降(P<0.05)。与对照组治疗后比较,外周血Th17,IL-6,IL-17A,hs-CRP,Hcy水平下降更明显(P<0.05)。对照组不良反应发生率高于观察组(P<0.05)。结论:涤痰汤加减治疗痰浊阻窍型癫痫(强直-阵孪发作)患儿疗效确切且安全,能够改善患儿临床症状和改善脑电图。能提高患儿免疫球蛋白水平,降低患儿外周血中Th17,IL-6,IL-17A水平,调节机体免疫功能,降低不良反应发生率。
Objective:To observe the clinical efficacy of Ditantang on phlegm turbid-blocked obstruction type tetan-burst twins in children with epilepsy and its effect on immunoglobulin,Peripheral blood helper T cells 17(Th17),interleukin-6(IL-6)and interleukin-17 A(IL-17 A)in children with epilepsy.Method:The random distribution sequences of 100 children generated by the random number table method were placed in sealed envelopes,and the subjects were divided into the corresponding experimental group and treatment group.Control group was treated with sodium valproate oral solution,and treatment group was also treated with Ditantang in addition to the therapy of control group.The total course of treatment was 3 months.The changes of immunoglobulin M(IgM),immunoglobulin A(IgA),immunoglobulin G(IgG),peripheral blood Th17 cells,IL-6,IL-17 A,C-reactive protein(hs-CRP),blood homocysteine(Hcy)and the adverse reactions were detected before and after treatment in two groups.The changes in the number of seizures,duration of seizures and EEG before treatment and 3 months after treatment were compared between the two groups.Result:Three months after the treatment of phlegm-blocking obstruction type tetan-burst twin epilepsy with Ditantang combined with sodium valproate,the results showed that the total effective rate of treatment group was superior to that of control group,with statistically significant differences(P<0.05).After treatment,treatment group was superior to control group in the reduction of epilepsy score(P<0.05).Compared with before treatment,the levels of IgG,IgA and IgM in treatment group were significantly increased(P<0.05),while the levels of Th17,IL-6,IL-17 A,hs-CRP and Hcy in peripheral blood were significantly decreased.Compared with control group,the levels of Th17,IL-6,IL-17 A,hs-CRP and Hcy in peripheral blood decreased significantly after treatment(P<0.05).The incidence of adverse reactions in control group was significantly higher than that in treatment group(P<0.05).Conclusion:Ditantang is effective and safe
作者
黄晓利
龙易勤
余宾
HUANG Xiao-li;LONG Yi-qin;YU Bin(The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Liuzhou Maternity and Child Healthcare Hospital,Liuzhou 545001,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第12期114-120,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
柳州市博士联合会软科学研究项目(20181223)
广西区中医药局自筹经费科研课题项目(GZZC2019187)。
关键词
涤痰汤
痰浊阻窍型小儿癫痫
强直-阵挛性发作
临床疗效
免疫球蛋白
Th17细胞因子
Ditantang
children with phlegm-turbid obstruction epilepsy
tetane-burst twin
clinical efficacy
immunoglobulin
Th17 cells and related factors
