摘要
目的观察调和阴阳针刺法治疗脾虚痰盛型小儿癫痫的临床疗效。方法纳入脾虚痰盛型儿童癫痫患者118例,用随机数字表法随机分为针刺组与西药组,每组59例。西药组予口服丙戊酸钠片治疗,针刺组在西药组口服药物治疗基础上予调和阴阳针刺治疗。观察两组治疗前后中医证候积分、癫痫每次发作持续时间、每月发作次数、脑电活动情况以及血清神经功能指标[神经元特异性烯醇化酶(neuron-specific enolase,NES)、s100β蛋白和胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)]水平的变化。比较两组临床临床疗效和复发率。结果针刺组总有效率为96.4%,明显高于西药组的86.0%(P<0.05)。两组治疗后中医证候积分各单项评分均较同组治疗前降低(P<0.05),且针刺组治疗后上述评分均低于西药组(P<0.05)。两组治疗后癫痫每次发作持续时间和每月发作次数均较同组治疗前降低(P<0.05),且针刺组治疗后均低于西药组(P<0.05)。两组治疗后血清NES、GFAP和s100β蛋白水平均较同组治疗前降低(P<0.05),且针刺组治疗后均低于西药组(P<0.05)。两组治疗后脑电活动指标中θ波功率均较同组治疗前升高(P<0.05),且针刺组高于西药组(P<0.05)。随访时,针刺组复发率为3.7%,明显低于对照组的18.4%(P<0.05)。结论在药物治疗基础上,调和阴阳针刺治疗脾虚痰盛型小儿癫痫可提高临床疗效,减少发作次数,缩短单次发作持续时间,改善血清神经功能相关指标,对脑电活动有一定的影响。
Objective To observe the clinical effect of reconciling Yin and Yang by acupuncture on infantile epilepsy with spleen deficiency and phlegm excess pattern.Method A total of 118 children with epilepsy of spleen deficiency and phlegm excess pattern were randomly divided into an acupuncture group and a Western medication group,with 59 cases in each group.The patients in the Western medication group were treated with oral sodium Valproate tablets,and the patients in the acupuncture group were treated with reconciling Yin and Yang method by acupuncture in addition to the oral medication in the Western medication group.Before and after treatment,the TCM syndrome score,the duration of each seizure,the number of seizures per month,brain electrical activity,and serum neurological function indexes[neuron-specific enolase(NES),s100βprotein and glial fibrillary acidic protein(GFAP)]levels were observed in the two groups.The clinical efficacy and recurrence rate were compared between the two groups.Result The total effective rate was 96.4%in the acupuncture group,which was significantly higher than 86.0%in the Western medication group(P<0.05).After treatment,the individual scores of the TCM syndrome score decreased in both groups compared with those before treatment in the same group(P<0.05),and the above scores were lower in the acupuncture group than in the Western medicine group(P<0.05).The duration of each seizure and the number of seizures per month were lower in both groups than before treatment(P<0.05),and the acupuncture group had lower scores than the Western medicine group after treatment(P<0.05).The serum NES,GFAP and s100βprotein levels decreased in both groups after treatment compared with those before treatment(P<0.05),and were lower in the acupuncture group than in the Western medicine group after treatment(P<0.05).Theθwave power in the EEG activity index increased in both groups after treatment compared with the same group before treatment(P<0.05),and was higher in the acupuncture group than in the Western
作者
王久胜
刘玉玲
王心羽
张方方
WANG Jiusheng;LIU Yuling;WANG Xinyu;ZHANG Fangfang(Shangqiu First People’s Hospital,Shangqiu 476000,China;Shangqiu Hospital of Traditional Chinese Medicine,Shangqiu 476000,China)
出处
《上海针灸杂志》
CSCD
2023年第6期598-603,共6页
Shanghai Journal of Acupuncture and Moxibustion
基金
河南省中医药科学研究专项课题(20-21ZY2292)。
关键词
针刺疗法
针药并用
调和阴阳
癫痫
脑电活动
神经功能
脾虚痰盛
儿童
Acupuncture therapy
Acupuncture medication combined
Reconcile Yin and Yang
Epilepsy
Brain electrical activity
Neurological function
Spleen deficiency and phlegm excess
Children
