摘要
目的探讨乌拉地尔注射液强化降压对高血压脑出血患者的临床效果。方法将2020年1月至2021年12月就诊于睢县人民医院的高血压脑出血患者82人作为研究对象。全部入组患者依据随机数字表的方法随机分为两组,对照组41例,观察组41例。对照组在常规处置方案的基础上,采取常规乌拉地尔的处理方法。观察组在常规处置方案的基础上,采取乌拉地尔的强化降压处理方法。对比两组患者治疗前后的脑血肿体积、美国国立卫生院神经功能缺损评分(NIHSS)、血清炎性因子变化情况、血清氧化应激指标、血液流变学指标变化情况以及两组并发症的发生率情况。结果在实施治疗14 d之后,对照组和观察组的脑血肿体积、NIHSS评分、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)、全血高切黏度、血浆黏度、全血低切黏度、纤维蛋白原(FIB)较治疗之前均明显降低,对照组和观察组的超氧化物歧化酶(SOD)较治疗之前均明显增高,差异均有统计学意义(P<0.05),且观察组的脑血肿体积、NIHSS评分、hs-CRP、TNF-α、MDA、全血高切黏度、血浆黏度、全血低切黏度、FIB均显著低于对照组,观察组的SOD显著高于对照组,差异均有统计学意义(P<0.05)。两组患者用药过程中各类并发症的发生率差异无统计学意义(P>0.05)。结论与常规的干预策略比较,乌拉地尔强化降压使用策略可以显著减少颅内血肿的形成,提高其对大脑的保护作用,同时还可以降低氧化应激、炎症反应严重程度,从而改善大脑的血液循环。
Objective To investigate the clinical effect of Urapidil injection on enhancing blood pressure reduction in patients with hypertensive cerebral hemorrhage.Methods A total of 82 hypertensive intracerebral hemorrhage patients who were admitted to Sui County People's Hospital for treatment from January 2020 to December 2021 were selected as the study subjects.All enrolled patients were randomly divided into two groups using a random number table:a control group of 41 cases and an observation group of 41 cases.On the basis of the conventional disposal plan,the control group adopted the conventional treatment method of urapidil.On the basis of the conventional disposal plan,the observation group adopted the enhanced blood pressure reduction treatment method of Uladipine.Compare the volume of cerebral hematoma,National Institutes of Health Neurological Deficiency Scale(NIHSS),changes in serum inflammatory factors,and changes in serum oxidative stress indicators between two groups of patients before and after treatment.Compare the changes in hemorheological indicators between two groups of patients before and after treatment.Compare the incidence of complications between two groups.Results After 14 days of treatment,the volume of cerebral hematoma,NIHSS score,high-sensitivity C-reactive protein(hs-CRP),Tumor necrosis factor-α(TNF-α),Malondialdehyde(MDA),whole blood high shear viscosity,plasma viscosity,whole blood low shear viscosity and fibrinogen(FIB)in the control group and observation group were significantly lower than those before treatment,the levels of superoxide dismutase(SOD)in control group and observation group were significantly higher than those before treatment,and the differences were statistically significant(P<0.05),the volume of cerebral hematoma,NIHSS score,hs-CRP,TNF-α,MDA,whole blood high shear viscosity,plasma viscosity,whole blood low shear viscosity and FIB in the observation group were significantly lower than those in the control group,the SOD level in the observation group was significantl
作者
周鹏
ZHOU Peng(Department of Neurology Third Ward,Sui County People's Hospital,Shangqiu Henan 476900,China)
出处
《临床研究》
2024年第5期48-52,共5页
Clinical Research
关键词
乌拉地尔
强化降压
高血压脑出血
炎性因子
血液流变学指标
uradil
strengthen blood pressure reduction
hypertensive cerebral hemorrhage
inflammatory factors
hemorheological indicators
