摘要
长链非编码RNA(long non-coding RNA, lncRNA)是一类长度大于200个核苷酸的非编码RNA。随着研究不断深入,越来越多的证据表明lncRNA广泛参与调控机体病理生理过程,影响着人类疾病与肿瘤的发生发展。HAGLR反义长链非编码RNA(HAGLR opposite strand long non-coding RNA, lncRNA HAGLROS)在诸多肿瘤中呈异常高表达,对肿瘤的恶性生物学行为起重要的调控作用。本文就lncRNA HAGLROS在肿瘤中的表达与调控机制做一简要综述。
Long noncoding RNAs(lncRNAs) are a group of noncoding RNAs of more than 200 nucleotides in length. Accumulating research has unearthed increasing evidence that lncRNA wass are widely involved in the regulation of pathophysiological processes and affect the establishment and progression of human diseases including cancers. HAGLR opposite-strand lncRNA is highly expressed in many tumors, playing important roles in regulating tumors’ malignant behaviors. This paper reviews the expression and mechanisms of action of the HAGLR opposite-strand lncRNA in tumors.
作者
刘浪
王海存
刘广麟
高欣
赵俞乔
姜兴明
LIU Lang;WANG Haicun;LIU Guanglin;GAO Xin;ZHAO Yuqiao;JIANG Xingming(Department of HPB Surgery,the 2nd Affiliated Hospital of Harbin Medical University,Harbin 150086,China)
出处
《中国比较医学杂志》
CAS
北大核心
2022年第5期102-106,共5页
Chinese Journal of Comparative Medicine
基金
黑龙江省自然科学基金(LH2020H058)
湖北陈孝平科技发展基金(CXPJJH12000002-2020015)
国家自然科学基金(81602088)。
