摘要
目的探讨颈动脉支架植入术后血清长链非编码RNA(LncRNA)结直肠肿瘤差异表达基因(CRNDE)水平及临床意义。方法选取2018年1月至2019年6月在邢台市人民医院接受颈动脉支架植入术治疗的173例颈动脉狭窄性急性缺血性脑卒中(AIS)患者作为研究对象。采用实时荧光定量聚合酶链反应(RT-qPCR)法检测患者血清LncRNA CRNDE相对表达量,并分析其与预后的关系。结果173例颈动脉狭窄性AIS患者支架植入术后预后不良发生率为39.88%(69/173)。预后不良组患者血清LncRNA CRNDE相对表达量为(1.35±0.34)%,显著高于预后良好组[(0.93±0.19)%](P<0.001)。Logistic回归分析显示,出血转化、脑卒中病灶数、LncRNA CRNDE与颈动脉狭窄性AIS患者预后关系密切。模型B(出血转化+脑卒中病灶数+LncRNA CRNDE)评估颈动脉狭窄性AIS患者预后的效能,高于LncRNA CRNDE、模型A(出血转化+脑卒中病灶数)(Z=2.603,P=0.009;Z=2.945,P=0.003)。结论LncRNA CRNDE与颈动脉狭窄性AIS患者支架植入术后预后关系密切,检测血清LncRNA CRNDE表达有助于评估患者预后。
Objective To investigate the serum long-chain non-coding RNA colorectal tumor differentially expressed(LncRNA CRNDE)level after carotid artery stenting,and to discuss its clinical significance.Methods A total of 173 acute ischemic stroke(AIS)patients with carotid stenosis,who received carotid stent implantation in the Xingtai Municipal People’s Hospital of China between January 2018 and June 2019,were selected as the study subjects.Real-time fluorescence quantitative PCR(RT-qPCR)was used to detect the relative expression of serum LncRNA CRNDE in patients with carotid stenosis AIS,and its relationship with prognosis was analyzed.Results The incidence of poor prognosis in 173 patients with carotid stenosis AIS after stent implantation was 39.88%(69/173).The relative expression of serum LncRNA CRNDE in the poor prognosis group was(1.35±0.34)%,which was significantly higher than(0.93±0.19)%in the good prognosis group(P<0.001).Logistic regression analysis showed that hemorrhagic transformation,number of stroke lesions and serum LncRNA CRNDE level were closely related to the prognosis of patients with carotid stenosis AIS.The efficacy of model B(hemorrhagic transformation+number of stroke lesions+LncRNA CRNDE)in evaluating the prognosis of patients with carotid stenosis AIS was better than LncRNA CRNDE and model A(hemorrhagic transformation+number of stroke lesions),the differences were statistically significant(Z=2.603,P=0.009 and Z=2.945,P=0.003 respectively).Conclusion Serum LncRNA CRNDE expression level carries a close relationship to the prognosis of patients with carotid stenosis AIS after receiving carotid artery stenting.The detection of serum LncRNA CRNDE expression is helpful for assessing the prognosis of patients.(J Intervent Radiol,2021,30:707-710)
作者
李爽
王建民
胡沛霖
LI Shuang;WANG Jianmin;HU Peilin(Division I,Department of Neurology,Xingtai Municipal People’s Hospital,Xingtai,Hebei Province 054000,China)
出处
《介入放射学杂志》
CSCD
北大核心
2021年第7期707-710,共4页
Journal of Interventional Radiology
关键词
颈动脉支架植入术
长链非编码RNA结直肠肿瘤差异表达基因
预后
carotid stent implantation
long-chain non-coding RNA differential gene expression in colorectal cancer
prognosis
