摘要
CROM抗原是一种直接链接在红细胞膜外GPI上的抗原,近年来CROM抗原的研究有了许多新进展和发现,本文就目前国内外的一些研究报道,做一简略综述。1 基因CROM抗原的基因位点在1号染色体长臂3区2带;1q32.2,基因名:CROM/DAF或CD55,基因长:46 495 bp, 基因编号:1604,基因库注册号:NG;07465.1(DNA基因组),基因有10个外显子(图1)。
CROM antigen is a kind of expression in GPI blood group antigen on the cell membrane, is Ⅳ transmembrane protein, also known as the decay accelerating factor(DAF), complement regulatory proteins, and membrane CD55 differentiation antigens. The peptide chain has four ring-folded structures in which all CROM antigens are expressed. The main function of CROM glycoprotein is to regulate the complement system to protect host cells and tissues from damage by controlling the amount of complement C3 and adjusting the amount of inhibiting the production of C5. CROM antigens are polymorphic and missense mutations lead to different antigenicity expressions. CROM antigens can trigger a mild transfusion hemolysis.
出处
《临床血液学杂志》
CAS
2022年第2期149-153,共5页
Journal of Clinical Hematology
关键词
CROM抗原
补体调节蛋白
衰变加速因子
膜分化抗原
输血反应
CROM antigen
complement regulatory protein
decay acceleration factor
membrane-differentiated antigen
blood transfusion reaction
