摘要
KX血型抗原是一个重要的红细胞膜抗原,在膜上与Kell抗原有关联性,二者在抗原表达上相关,且相互影响。KX抗原的缺失,表型为Mcleod综合征,是由于X染色突变引起,是一种遗传性疾病。本文就KX抗原近几年来的研究进展,做一简略综述。1 基因KX抗原的基因位点在X染色体长臂2区1带1亚带;Xp21.1。基因名:XK,基因长:53 251 bp, 基因编号:7504,基因库注册号:NG007473.1(DNA基因组).
KX antigen is one of the two "phosphorylated palmitate alcoholated proteins" on the membrane. It is a Ⅲ transmembrane protein. It is linked to the Kell antigen glycoprotein on the membrane and is related to the Kell glycoprotein penetration through the membrane. The phenotype of red blood cells lacking KX antigen is the Mcleod phenotype. This phenotype is clinically expressed as Mcleod syndrome which is a genetic disease. Anti-KX antibodies can cause transfusion hemolysis.
出处
《临床血液学杂志》
CAS
2021年第6期445-448,共4页
Journal of Clinical Hematology
