摘要
1945年Callender在1位名叫Lutheran的献血者输血给1位SLE的患者后,患者产生了抗Lua抗体,从而发现了Lu抗原。抗原的名字以先证者(献血者)的名字命名。到1995年Lu抗原的mRNA复制成功,2019年国际输血协会(ISBT)确认了该系统有25个抗原,其中多态性抗原有3个,高频抗原20个,低频抗原2个。本文就Lu抗原近年来的研究进展,做一简略综述。
The Lu gene and the BCAM gene transcribe two transcripts,and the two transcripts separately translate the Lu glycoprotein(CD239)and the cell adhesion factor B glycoprotein(B-CAM).Proteins(IgSF),all express Lu antigen.The Lu(a-b-)phenotype expressed by gene mutation is called Lunull phenotype.It is affected by mutations in the GATA1 gene and KLF1 gene,and the resulting phenotype is called the Lumod phenotype.This gene is also called the In(Lu)gene.Lu glycoprotein is one of the important immune mechanisms.This article details the epitope of Lu antigen.Anti-Lu generally does not cause hemolysis in neonates,but may cause transfusion hemolysis.
出处
《临床血液学杂志》
CAS
2021年第8期593-599,共7页
Journal of Clinical Hematology
