摘要
目的探讨内蒙古地区蒙古族人群RH(C/c/E/e)、Lw(Lw^(a)/Lw^(b))、Duffy(Fy^(a)/Fy^(b))、Kidd(Jk^(a)/Jk^(b))、MNS(M/N/S/s/Mur)、Scianna(Sc2)、Colton(Co^(a)/Co^(b))、Dombrock(Do^(a)/Do^(b))、Kell(K/k/Kp^(a)/Kp^(b))、Diego(Di^(a)/Di^(b)/Wr^(a)/Wr^(b))、Yt(Yt^(a)/Yt^(b))和Lutheran(Lu^(a)/Lu^(b))血型系统抗原基因的分布情况,为蒙古族血液学研究、精准输血、临床科学合理使用血液及稀有血型库建设等提供数据支撑。方法采用荧光PCR法对220名内蒙古蒙古族人群12种血型系统进行基因分型和统计学分析。结果内蒙古蒙古族人群12个稀有血型基因频率依次为:(1)RhCE血型系统基因频率为:C=0.6136,c=0.3864,E=0.2659,e=0.7341;MNS血型基因频率为M=0.6091,N=0.3909,S=0.0636,s=0.9318,Mur=0;Duffy血型基因频率为:Fy^(a)=0.8568,Fy^(b)=0.1432;Kidd血型基因频率为:Jk^(a)=0.5227,Jk^(b)=0.4773;Diego血型基因频率为:Di^(a)=0.0273,Di^(b)=0.9727,Wr^(a)=0,Wr^(b)=1;Dombrock血型基因频率为:Do^(a)=0.1636,Do^(b)=0.8364。(2)Kell血型基因频率为:K=0.0023,k=0.9977,kp^(a)=0.0091,Kp^(b)=0.9909;Yt血型基因频率为:Yt^(a)=0.9864,Yt^(b)=0.0136。(3)Lw血型基因频率为:Lw^(a)=1,Lw^(b)=0;Scianna血型基因频率为:Sc2=0;Colton血型基因频率为:Co^(a)=1,Co^(b)=0;Lutheran血型基因频率为:Lu^(a)=0,Lu^(b)=1。结论内蒙古地区蒙古族人群RHCE、MNS、Duffy、Kidd、Diego、Dombrock血型呈多态性分布具有其独特的分布特点。Kell和Yt分布与维吾尔族、柯尔克孜族、哈萨克族等人群的分布具有一定的相似性。Lw、Scianna、Colton和Lutheran血型系统呈单态性分布。
Objective To investigate the Mongolian population RH(C/c/E/e),Lw(Lwa/Lwb),Duffy(Fya/Fyb),Kidd(Jka/Jkb),MNS(M/N/S/s/Mur),Scianna(Sc2),Colton(Coa/Cob),Dombrock(Doa/Dob),Kell(K/k/Kpa/Kpb),Diego(Dia/Dib/Wra/Wrb),Yt(Yta/Ytb)And Lutheran(Lua/Lub)blood group system antigen gene polymorphism distribution,providing data support for Mongolian hematology research,precision blood transfusion,clinical scientific rational use of blood,and rare blood group library construction.Methods Twelve blood groups of 220 Mongolian people in Inner Mongolia were genotyped and analyzed by fluorescent PCR.Results The gene frequency of twelve blood group systems were as follows:RhCE:C=0.6136,c=0.3864,E=0.2659,e=0.7341;MNS:M=0.6091,N=0.3909,S=0.0636,s=0.9318,Mur=0;Duffy:Fya=0.8568,Fyb=0.1432;Kidd:Jka=0.5227,Jkb=0.4773;Diego:Dia=0.0273,Dib=0.9727,Wra=0,Wrb=1;Dombrock:Doa=0.1636,Dob=0.8364.Kell:K=0.0023,k=0.9977,kpa=0.0091,Kpb=0.9909;Yt:Yta=0.9864,Ytb=0.0136.Lw:Lwa=1,Lwb=0;Scianna:Sc2=0;Colton:Coa=1,Cob=0;Lutheran:Lua=0,Lub=1.Conclusion The distribution of gene frequencies of five rare blood groups of RHCE,MNS,Duffy,Kidd,Diego,and Dombrock blood groups in the Mongolian population in Inner Mongolia have a polymorphic distribution and have their unique distribution characteristics.The distribution of Kell and Yt is similar to the distribution of Uygur,Kirgiz,and Kazak.The gene frequency distribution of Lw,Scianna,Colton,Kell,Yt and Lutheran blood group systems was monomorphic.
作者
王荣鹏
郑洋洋
陈凤
WANG Rong-peng;ZHENG Yang-yang;CHEN Feng(Inner Mongolia Medical University,Hohhot 010110 China;Baotou Medical College,Baotou 014010 China;Department of Clinical Transfusion,Inner Mongolia People's Hospital,Hohhot 010017 China)
出处
《内蒙古医学杂志》
2021年第6期641-645,651,F0002,共7页
Inner Mongolia Medical Journal
关键词
红细胞血型
基因多态性
精准输血
蒙古族
rare blood type
gene polymorphism
precision blood transfusion
mongolian
