摘要
植物细胞、细菌细胞和哺乳动物细胞均可生成和分泌细胞外囊泡,囊泡内含有蛋白质、核酸、脂质和小分子代谢物。在发现早期,细胞外囊泡只被认为是细胞处置细胞废弃物的一种方式,后发现这些囊泡可在不同细胞之间传递活性物质并改变囊泡受体细胞表型。越来越多的研究证实囊泡是细胞间短程和长程通讯的一种新机制,是细胞间通讯的新范式。细胞外囊泡具有广泛的生理病理作用,既可直接用作药物也可作为药物递送载体,还可作为药物靶标和生物标志物。综述植物、细菌和哺乳动物等不同细胞来源的细胞外囊泡在肿瘤靶向治疗中的作用和应用及工程化策略。
Plant cells,bacterial cells,and mammalian cells can produce and secret extracellular vesicles(EVs)encapsulated with proteins,nucleic acids,lipids,and small molecules.At the very beginning of research on EV,EVs were thought to function solely as a way to dispose cellular waste.Later on,EVs were found to be able to carry and transfer bioactive substances between cells and change the phenotype of the recipient cells.More and more studies have confirmed that EVs are novel mediators for short-and long-range intercellular communication and new pattern of intercellular communication.EVs have broad physiological and pathological effects and can serve as diagnostic biomarkers,drugs,drug targets,and drug carriers.In this paper,we review the effect,application,and engineering strategies of EVs from different sources in targeted cancer therapy.
作者
张宁
谢姝钰
常国欣
陈延
王岩
张静
邱宏
ZHANG Ning;XIE Shuyu;CHANG Guoxin;CHEN Yan;WANG Yan;ZHANG Jing;QIU Hong(Carbohydrate-based Drug Research Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;School of Pharmacy,University of Chinese Academy of Sciences,Beijing 100049,China;School of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing 210023,China;School of Chinese Materia Medica,Guangdong Pharmaceutical University,Guangzhou 510006,China;Key Laboratory of Functional Molecular Engineering of Guangdong Province,School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou 510640,China;The Artemisinin Research Center,Guangzhou University of Chinese Medicine,Guangzhou 510405,China)
出处
《药学进展》
CAS
2022年第2期93-115,共23页
Progress in Pharmaceutical Sciences
基金
上海市浦江人才计划资助项目(No.19PJ1411300)。
关键词
细胞外囊泡
肿瘤
靶向治疗
extracellular vesicle
cancer
targeted therapy
