摘要
外泌体是由细胞主动向外分泌的双层囊泡小体,可携带多种蛋白质、核酸和脂质等在体液中循环,具有物质"运输载体"的作用,能够将内含物质运输到周围细胞中进行细胞间的物质运输和信息交流,从而参与多种生理及病理学过程,如递呈抗原、促进肿瘤生长与迁移、修复损伤组织等。大量研究证实,外泌体对疾病治疗具有决定性帮助,特别是在疾病早期诊断和作为药物载体进行靶向治疗方面拥有广阔的应用前景。论文从外泌体的发生机制、主要成分和功能、外泌体与疾病发生以及外泌体的应用等方面进行综述。
Exosomes are series of subcellular lipid bilayer membranous nanovesicles, which contain proteins, nucleic acids and lipids. They are secreted by all cells and circulate in all body fluids. Exosomes, as delivery vehicles, can transport its internal substances to the peripheral cells to exchange materials and information transportation between the cells and participate in a variety of physiological and pathological process, such as antigen presenting, promoting tumor growth and migration, repairing the damaged tissues. A plenty of studies have shown exosomes play a decisive role in the treatment of disease, especially in the early diagnosis of disease and drug carriers for targeted therapy, which have a extensive application prospects. Therefore, this review summarized exosome secreting mechanism, main composition and function, occurrence relationship between exosomes and disease and its application.
出处
《动物医学进展》
北大核心
2016年第12期90-94,共5页
Progress In Veterinary Medicine
基金
新疆维吾尔自治区科技支疆项目(210-60879)
新疆维吾尔自治区高层次引进人才项目(111001/45051)
