摘要
目的探讨糖尿病足溃疡分泌物病原菌分布,多重耐药菌(MDROs)耐药性及危险因素,为科学防控提供依据。方法通过回顾性调查,对某糖尿病足溃疡患者送检病原学标本检测结果及临床资料进行统计分析。结果共分离出病原菌210株,其中革兰阴性菌112株(占53.33%),革兰阳性菌90株(占42.86%)、真菌8株(占3.81%);前2位病原菌分别为大肠埃希菌、金黄色葡萄球菌分别占25.71%,21.43%,共分离MDROs 113株,检出率为53.80%,最常检出的MDROs为大肠埃希菌,最常分离自Wagner 4级,未检出对万古霉素耐药的菌株,大肠埃希菌对多数抗菌药物耐药,已有对碳青霉烯类耐药菌株的检出。合并骨髓炎、重度感染.Wagner>3级是糖尿病足溃疡感染MDROs的独立影响因素(P<0.05)。结论糖尿病足溃疡分泌物中MRDOs检出率高,且对多种抗菌药物耐药,应针对高危因素加强防控。
Objective To investigate the distribution of pathogenic bacteria in the secretion of diabetic foot ulcer,the drug resistance of multiple drug-resistant bacteria(MDROs)and risk factors,so as to provide basis for scientific prevention and control.Methods Through retrospective investigation,the results and clinical data of diabetic foot ulcer were statistically analyzed.Results A total of 210 strains of pathogenic bacteria were isolated,in which 112 strains of Gram-negative bacteria accounted for 53.33%,90 strains of Gram-positive bacteria accounted for 42.86%,and 8 strains of fungi accounted for 3.81%.The top two pathogenic bacteria,Escherichia coli and staphylococcus aureus,accounted for 25.71% and 21.43%,respectively.A total of 113 MDROs strains were isolated,with a detection rate of 53.80%.The most commonly detected MDROs was Escherichia coli,which was most commonly isolated from Wagner grade 4.No vancomycin resistant strains were detected.The combination of osteomyelitis,severe infection and Wagner>3 were the independent influencing factors of diabetic foot ulcer infection with MDROs(P<0.05).Conclusion The detection rate of MRDOS in the secretion of diabetic foot ulcer is high,and it is resistant to a variety of antibiotics,so the prevention and control should be strengthened according to the high-risk factors.
作者
楼世贵
LOU Shi-gui(Clinical Laboratory,Second Peopled Hospital of Yuhuan,Yuhuan,Zhejiang 317605,China)
出处
《中国卫生检验杂志》
CAS
2021年第23期2865-2869,2873,共6页
Chinese Journal of Health Laboratory Technology
关键词
糖尿病足
溃疡
分泌物
病原菌
多重耐药
抗菌药物
耐药性
危险因素
Diabetic foot
Ulcer
Secretion
Pathogenic bacteria
Multiple drug resistance
Antibacterial drugs
Drug resistance
Risk factors
