摘要
糖尿病是以慢性高血糖为特征的一组疾病综合征,可导致一系列微血管及大血管并发症,易累及心血管、神经、视网膜、肾等。长期高糖环境常引发细胞氧化应激及活性氧类(ROS)生成,导致细胞核DNA损伤。ROS引发DNA链断裂后,DNA修复酶过度激活,进一步引起细胞慢性炎症、胰岛素抵抗等,加剧细胞代谢紊乱,引发糖尿病并发症。因此,深入了解DNA损伤修复过程与糖尿病及其并发症的关系,对寻找有效的糖尿病早期预防靶点有积极意义。
Diabetes mellitus is a group of disease syndromes characterized by chronic hyperglycemia,which can lead to a series of microvascular and macrovascular complications,easily involving cardiovascular system,nerve,retina,kidney and so on.Long term high glucose environment often leads to oxidative stress and reactive oxygen species(ROS)production,leading to nuclear DNA damage.After ROS inducing DNA strand breaks,DNA repair enzymes are over activated,which further leads to chronic inflammation and insulin resistance,aggravates the metabolic disorder of cells,and leads to diabetic complications.Therefore,understanding the relationship between DNA damage repair process and diabetes and its complications is of great significance to find effective targets for the early prevention of diabetes.
作者
陈诗梅
韦芳
CHEN Shimei;WEI Fang(Department of Ophthalmology,Shanghai General Hospital Affiliated to Shanghai Jiaotong University/National Clinical Research Center for Eyes Diseases/Shanghai Key Laboratory of Ocular Fundus Disease/Shanghai Engineering Center for Visual Science and Photomedicine/Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases,Shanghai 200080,China)
出处
《医学综述》
CAS
2021年第11期2203-2208,共6页
Medical Recapitulate
基金
国家自然科学基金(81970812)。
