摘要
目的探讨利拉鲁肽联合门冬胰岛素对血糖控制不佳2型糖尿病患者的疗效及胰岛β细胞功能和胰岛素抵抗的影响。方法筛选血糖控制不佳2型糖尿病患者共100例,采取随机数字表法分为对照组和观察组(各50例)。2组给予非药物和口服二甲双胍片降糖。对照组采取3餐前皮下注射门冬胰岛素注射液。观察组在对照组基础上给予利拉鲁肽注射液。2组连续治疗12周。比较2组血糖水平、临床疗效和安全性。检测2组胰岛β细胞功能和胰岛素抵抗。结果与对照组比较,观察组患者空腹血糖、餐后2 h血糖、糖化血红蛋白水平下降更显著(P<0.01);观察组患者总有效率为96%,显著多于对照组(80%,χ^2=4.640,P=0.031),差异有统计学意义;观察组患者的不良反应发生率为34%,对照组为32%,差异无统计学意义(P>0.05)。治疗后,观察组患者C肽、餐后2 h C肽、HOMA胰岛β细胞功能指数明显高于对照组,HOMA胰岛素抵抗指数显著低于对照组(P<0.01)。结论利拉鲁肽联合门冬胰岛素治疗血糖控制不佳2型糖尿病可提高降糖效果,且安全性好,改善患者的胰岛β细胞功能可能是其疗效之一。
Objective To investigate into the efficacy of Laluralurin combined with Mentholin insulin in treating patients of type 2 diabetes with poor blood glucose control and into the effect onβ-cell function of insulin and insulin resistance.Methods One hundred patients of type 2 diabetes with poor blood glucose control were randomly divided into an observation group and control group with 50 patients in each group.Both groups were given non-pharmaceutical and oral metformin tablets for hypoglycemia.The control group was given hypodermic injection of menthol insulin before three meals.Contrasted with the control group,the observation group was given Laluralurin.Both groups were treated for twelve weeks.Factors including blood glucose,efficacy and safety were compared between them.β-cell function of insulin and insulin resistance were detected in the two groups.Results Compared with the control group,fasting blood-glucose,2 h postprandial blood glucose and glycosylated hemoglobin were obviously decreased(P<0.01).Overall effective rate for the obser-vation group was 96%,remarkably higher than that of control group(80%,χ^2=4.640,P=0.031),there was statistically significant difference between them.Adverse reaction rate was 34%for the observation group and 32%for the control group,but there was no statistically significant difference between them(P>0.05).After treatment,fasting C-peptide,2 h postprandial C-peptide,and HOMAβ-cell function of insulin were obviously higher,while HOMA insulin resistance was lower than that of control group(P<0.01).Conclusion The efficacy of Laluralurin combined with Mentholin insulin in treating patients of type 2 diabetes with poor blood glucose control is significant and safe,and regulation ofβ-cell function of insulin may be one of it’s effective ways.
作者
吴金婵
陈娟
冯光球
Wu Jin-chan;Chen Juan;Feng Guang-qiu(Health Care Center,Hainan Provincial People's Hospital,Haikou 570311,China)
出处
《兰州大学学报（医学版）》
CAS
2018年第6期40-44,共5页
Journal of Lanzhou University（Medical Sciences）
关键词
利拉鲁肽
门冬胰岛素
血糖控制不佳2型糖尿病
胰岛Β细胞功能
胰岛素抵抗
Laluralurin
Mentholin insulin
type 2 diabetes with poor blood glucose control
β-cell function of insulin
insulin resistance
