摘要
目的:探讨二甲双胍联合益气补血法对2型糖尿病合并糖尿病肾病患者HGF、肌酐清除率及临床疗效的影响。方法:回顾性研究我院2型糖尿病合并糖尿病肾病患者120例,按照就诊先后顺序分为实验组和对照组,每组各60例,对照组患者采取二甲双胍治疗,实验组患者采取二甲双胍联合益气补血法进行治疗。比较治疗前后两组患者血清肝细胞生长因子(Hepatocyte growth factor,HGF)、血清胱抑素C(Cystatin C)、转化生长因子-β1(Transforming growth factor-β1,TGF-β1)、血清肌酐(Serum creat imine,SCr)、血尿素氮(Blood urea nitrogen,BUN)、肌酐清除率(Serum creat inine clearance rate,Ccr)及24 h尿蛋白定量(24 h Upro)水平变化,同时比较治疗结束后两组临床疗效。结果:与治疗前相比,两组患者的HGF、Ccr显著升高,TGF-β1、Cys C、Scr、BUN及24 h Upro显著降低(P<0.05);治疗结束后与对照组相比,实验组患者HGF水平较高(P<0.05);Cys C、TGF-β1水平较低(P<0.05);SCr、BUN、24 h Upro水平较低(P<0.05);Ccr水平较高(P<0.05)。结论:二甲双胍联合益气补血法能够提高2型糖尿病合并糖尿病肾病的临床疗效,推测其机制可能与降低Cys C、TGF-β1、SCr、BUN、24 h Upro水平,提高HGF、CCr水平有关。
Objective：To investigate the effect of metformin combined with replenish Qi and tonify blood method HGF,creatinine clearance rate and clinical efficacy in type 2 diabetic patients with diabetic nephropathy. Methods：120 type 2 diabetic patients with diabetic nephropathy from our hospital were selected and randomly divided into the control group and the experiment group with 60 cases in each group.The control group were treated by metformin and the experiment group were treated by metformin combined with replenish Qi and tonify blood method. The HGF,cystatin C,transforming growth factor-β1,SCr,BUN,Ccr,24 h Upro and clinical curative effect. Results：Compared with before treatment,HGF and Ccr levels were higher（P〈0.05）,TGF-β1、Cys C、Scr、BUN and 24 h Upro levels were lower（P〈0.05）.Compared with the control group after treatment,HGF level were higher（P〈0.05）,the Cys C and TGF-β1levels were lower（P〈0.05）,the SCr,BUN and 24 h Upro level were lower（P〈0.05）,Ccr level were higher（P〈0.05）. Conclusion：Metformin combined with replenish Qi and tonify blood method can improve the curative effect of type 2 diabetes mellitus and diabetic nephropathy. It is speculated that the mechanism may be related to reduced Cys C,TGF-β1,SCR,BUN,24 h Upro levels,related to the improvement of the level of HGF and CCR.
出处
《辽宁中医药大学学报》
CAS
2016年第8期211-213,共3页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
二甲双胍
益气补血法
2型糖尿病合并糖尿病肾病
肝细胞生长因子
肌酐清除率
metformin
replenish Qi and tonify blood method
type 2 diabetes mellitus and diabetic nephropathy
HGF
creatinine clearance rate
