摘要
目的:糖尿病发病率逐年上升并出现低龄化趋势,降糖药的研究成为热点。本文从臭茉莉根茎叶三个植物部位中提取得到不同极性提取物,研究其对α-葡萄糖苷酶及DPP-4的抑制作用。方法:本文采用系统溶剂提取法得到臭茉莉不同极性部位,并测试其对α-葡萄糖苷酶及DPP-4的抑制作用。结果:实验结果发现,臭茉莉根的正己烷、正丁醇、氯仿提取物,臭茉莉茎的氯仿、正丁醇提取物,臭茉莉叶的甲醇、正丁醇、氯仿提取物对α-葡萄糖苷酶抑制作用较强。臭茉莉根的正丁醇提取物,臭茉莉茎的正丁醇、水B1提取物,臭茉莉叶的正丁醇、甲醇、四氯化碳提取物对DPP-4的抑制作用较强。结论:臭茉莉提取物对α-葡萄糖苷酶和DPP-4两种酶有一定的抑制作用,本文为臭茉莉降血糖及其活性成分的研究提供参考。
Objective:The incidence of diabetes is increasing year by year and the age of diabetes appears to be younger.The research on hypoglycemic drugs has become a hotspot.In this study,different polar extracts were extracted from three plant parts of Clerodendrum philippinum var.Simplex,and their inhibitory effects on a-glucosidase and DPP-4 were studied.Methods:In this paper,different polar parts of Clerodendrum philippinum var.Simplex were extracted by systematic solvent extraction method,and the inhibitory effects on a-glucosidase and DPP-4 were tested.Results:The experimental results showed that n-hexane,n-butanol,chloroform extract of the root,chloroform,nbutanol extract of the stem and methanol,n-butanol,chloroform extract of the leaf of Clerodendrum philippinum var.Simplex had the strongest inhibitory effect onα-glucosidase.The n-butanol extract of the root,n-butanol extract,water B1 extract of the stem,n-butanol extract,methanol extract and carbon tetrachloride extract of the leaf of Clerodendrum philippinum var.Simplex had the strongest inhibitory effect on DPP-4.Conclusions:The extract of Clerodendrum philippinum var.Simplex has certain inhibitory effects onα-glucosidase and DPP-4 enzymes.This study provides reference for the study on the hypoglycemic effects of Clerodendrum philippinum var.Simplex and its active components.
作者
凌兰鑫
徐津金
苏健
Ling lanxin;Xu jinjin;Su jian(Guangxi University of Chinese Medicine,Nanning 530200)
出处
《壮瑶药研究》
2022年第1期143-157,241,共16页
Research of Zhuang and Yao Ethnic Medicine
基金
壮瑶药协同创新中心(桂教科研〔2013〕20号)
广西壮瑶药重点实验室(桂科基字〔2014〕32号)
广西壮族自治区民族药资源与应用工程研究中心(桂发改高技函〔2020〕2605号)
广西中医药重点学科壮药学(GZXK-Z-20-64)
第八批广西壮族自治区特聘专家项目(桂人才通字〔2019〕13号)
广西高校中药药理重点实验室(J1700304)
关键词
臭茉莉
Α-葡萄糖苷酶
DPP-4
糖尿病
Clerodendrum philippinum var.Simplex
α-glucosidase
DPP-4
Diabetes
