摘要
高迁移率族蛋白B1（high mobility group protein box 1，HMGB1）是一组高度保守的DNA结合蛋白，存在于体内各种细胞的细胞核中，调控着细胞基因的转录。生理状态下HMGB1发挥着核结合蛋白的作用。当释放到细胞间隙后则会起到晚期炎症因子的作用。最近的研究提示，HMGB1不仅参与脓毒症、自身免疫性疾病、慢性肝病、恶性肿瘤等的致病过程，还可参与细胞损伤的修复或致病，在多种疾病及组织器官损伤、修复过程中发挥着重要作用。
High mobility group protein box 1 （HMGB1） is a highly conserved DNA binding pro- tein, which is found in the nucleus of a variety of cells in the body, regulating the transcription of cell genes. It plays a role of nuclear binding protein in physiological state. Once released into the cell gap, it perform- ances the role of inflammatory mediators. Recent studies showed that pathogenesis of HMGB1 not only in- volved in sepsis, autoirnmune diseases, chronic liver disease, malignant tumor, but also involved in cell in- jury repair, which plays important role in a variety of diseases, organ damage, repair process.
出处
《中国小儿急救医学》
CAS
2017年第8期606-609,615,共5页
Chinese Pediatric Emergency Medicine
基金
陕西省科学技术研究发展项目（2011K12-82）,西安市科学技术局医疗卫生研究项目（2016052SF/YX08）,陕西省科技统筹创新工程计划项目（重点产业创新链）（2016KTZDSF02-04）
关键词
高迁移率族蛋白B1
生物特性
临床疾病
High mobility group protein boxl
Physiological characteristics
Clinical disease
