摘要
丝裂原活化蛋白激酶/细胞外调节蛋白激酶(MAPK/ERK)信号通路参与调控肿瘤的生长和转移,而肿瘤的生长需要新生血管的维持,肿瘤血管的生成需要血管内皮细胞的参与,包括内皮细胞的增殖、迁移、侵袭。作为Ras/Raf/MEK/ERK途径是该网络信号的核心,本文就MAPK/ERK信号通路中各环节与肿瘤血管新生的联系做一综述,进一步研究其在抑制肿瘤生长方面做出推论。
MAPK/ERK signal pathway involves in the regulation of tumor growth and metastasis, and tumor growth cannot do without angiogenesis. Tumor angiogenesis requires the participation of vascular endothelial cells, including endothelial cell proliferation, migration and invasion. So as the core of this network signal： Ras/Raf/MEK/ERK path-way, this paper focus on the modulation between various MAPK/ERK signaling links and tumor angiogenesis, for mak-ing further study of the inferred in inhibiting tumor growth.
出处
《中国医药导报》
CAS
2015年第1期148-151,共4页
China Medical Herald
基金
国家自然科学基金(编号81372553)
