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MAPK信号转导通路与肿瘤侵袭转移 被引量：2

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摘要 侵袭和转移是恶性肿瘤的重要生物学特性之一，肿瘤的侵袭和转移是肿瘤细胞与宿主细胞及细胞外基质之间一系列复杂的、多步骤、多因素相互作用的动态过程。信号转导异常是其基本发生机制之一，其中丝裂原活化蛋白激酶（MAPK）信号通路具有重要地位。
作者 陈红芳（综述） 邓华瑜（审校）
机构地区 重庆医科大学基础医学院病理生理教研室
出处 《国际检验医学杂志》 CAS 2007年第6期551-553,共3页 International Journal of Laboratory Medicine
关键词 蛋白激酶类 有丝分裂原 信号传导 肿瘤侵润 肿瘤转移
分类号 R345 [医药卫生—基础医学]
  • 相关文献

参考文献16

  • 1Kobel M, Pohl G, Schmitt WD, et al. Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor [J]. Am J Pathol, 2005, 167(3): 879-885. 被引量：1
  • 2Reddy KB, Nabha SM, Atanaskova N. Role of MAP kinase in tumor progression and invasion [J]. Caneer Metastasis Rev, 2003, 22(4): 395-403. 被引量：1
  • 3Raviv Z, Kalie E, Seger R. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation [J]. J Cell Sci, 2004, 117(Pt 9): 1773-1784. 被引量：1
  • 4Dong C, Davis RJ, Flavell RA. Signaling by the JNK group of MAP kinases, c-jun N-terminal Kinase [J]. J Clin Immunol, 2001, 21(4): 253-257. 被引量：1
  • 5Obata T, Brown GE, Yaffe MB. MAP kinase pathways activated by stress: the p38 MAPK pathway [J]. Crit Care Med, 2000, 28(4 Suppl) : N67-N77. 被引量：1
  • 6田芳,缪泽鸿,章雄文,丁健.整合蛋白信号转导研究进展[J].生命科学,2005,17(3):240-245. 被引量：5
  • 7Tremblay PL, Auger FA, Huot J. Regulation of transendothelial migration of eolon eaneer eells by E-seleetin-mediated aetivation of p38 and ERK MAP kinases [J]. Oneogene, 2006, 25(50) : 6563- 6573. 被引量：1
  • 8Kranenburg O, Gebbink MF, Voest EE. Stimulation of angiogenesis by Ras proteins [J]. Biochim Biophys Acta, 2004, 1654 (1) : 23-37. 被引量：1
  • 9Shyu KG, Lin S, Lee CC, et al. Evodiamine inhibits in vitro angiogenesis: Implication for antitumorgenieity [J]. Life Sei, 2006, 78(19) : 2234-2243. 被引量：1
  • 10Qian D, Lin HY, Wang HM, et al. Involvement of ERK1/2 pathway in TGF-betal-indueed VEGF secretion in normal human eytotrophoblast cells [J]. Mol Reprod Dev, 2004, 68(2): 198- 204. 被引量：1

二级参考文献24

  • 1陈天星,杨慧,陈建伟,麻新梅.骨巨细胞瘤VEGF表达与MVD相关性研究[J].中国现代医学杂志,2004,14(15):48-49. 被引量：3
  • 2Shimaoka M, Takagi J, Springer T A. Conformational regulation of integrin structure and function. Annu Rev Biophys Biomol Struct, 2002, 31:485-516. 被引量：1
  • 3Li R, Mitra N, Gratkowski H, et al. Activation of integrin αⅡbβ3 by modulation of transmembrane helix associations.Science, 2003, 300:795-798. 被引量：1
  • 4Vinogradova O, Vaynberg J, Kong X, et al. Membrane-mediated structural transitions at the cytoplasmic face during integrin activation. Proc Natl Acad Sci USA, 2004, 101:4094-4099. 被引量：1
  • 5Barton S J, Travis M A, Askari J A, et al. Novel activating and inactivating mutations in the integrin β1 subunit A domain.Biochem J, 2004, 380:401-407. 被引量：1
  • 6Schwartz M A, Ginsberg M H. Networks and crosstalk:integrin signalling spreads. Nat Cell Biol, 2002, 4: E65-E68. 被引量：1
  • 7Schlaepfer D D, Mitra S K. Multiple connections link FAK to cell motility and invasion. Curr Opin Genet Dev, 2004, 14:92-101. 被引量：1
  • 8Parsons J T. Focal adhesion kinase: the first ten years. J Cell Sci, 2003, 116:1409-1416. 被引量：1
  • 9Schlaepfer D D, Mitra S K, Ilic D. Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta, 2004, 1692:77-102. 被引量：1
  • 10von Wichert G, Jiang G, Kostic A, et al. RPTP-α acts as a transducer of mechanical force on αv/β3-integrin-cytoskeleton linkages. J Cell Biol, 2003, 161:143-153. 被引量：1

共引文献5

同被引文献34

  • 1万芳,钟刚,何福仙,陈敏,关艳梅.ERK/MAPK信号通路激活与乳腺癌细胞浸润性生长的关系[J].医学研究生学报,2004,17(6):490-492. 被引量：17
  • 2毛华,黄纯炽,赵敏芳,宋卫生.p38MAPK信号传导通路调控VEGF诱导肝癌细胞黏附作用[J].世界华人消化杂志,2006,14(8):778-783. 被引量：17
  • 3郝玉琴,郑绘霞.MAPK/ERK信号传导通路在肿瘤治疗中作用机制的研究[J].中国麻风病皮肤杂志,2012,28(7):490-493. 被引量：1
  • 4Sadaria MR, Yu JA, Meng X, et al. Secretory phospholipase A2 mediates human esophageal adenocarcinoma cell growth and proliferation via ERK 1/2 pathway [J]. Anticancer Res,2013,33 (4) :1337 - 1342. 被引量：1
  • 5Waiters DM, Lindberg JM, Adair SJ, et al. Inhibition ofthe growth of patient-derived pancreatic cancer xenografts with the MEK inhibitor trametinib is augmented by combined treatment with the epidermal growth factor receptor/HER2 inhibitor lapatinib [ J ]. Neoplasia,2013, 15(2) :143 - 155. 被引量：1
  • 6Parente R, Trifir E, Cuozzo F, et al. Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival [ J ]. Oncol Rep,2013,29 (5) : 1999 - 2004. 被引量：1
  • 7Tormos AM, Arduini A, Ta|ens-Visconti R, et al. Liver- specific p38a deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice [J]. Hepatology, 2012 Nov 29. doi: 10. 1002/hep. 26174. 被引量：1
  • 8Guo YY, Wang WD, Wang J, et al. Receptor for activated C kinase 1 promotes hepatocellular carcinoma by enhancirrg mitogen-activated protein kinase kinase 7 activity [J]. Hepatology,2013,57( 1 ) :140 - 151. 被引量：1
  • 9Sun KK, Ji C, Li X, et al. Overexpression of high mobility group protein Bl correlates with the proliferation and metastasis of lung adenocarcinoma cells [ J ]. Mol Med Rep ,2013,7 (5) : 1678 - 1682. 被引量：1
  • 10Zhang S, Nie S, Huang D, et al. Polysaccharide from ganoderma atrum evokes antitumor activity via toll-like tceptor 4-mediated NF-KB and mitogen-activated protein kinase signaling pathways [ J ] J Agric Food Chem,2013,61 ( 15 ) :3676 - 3682. 被引量：1

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国际检验医学杂志
2007年 第6期

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