摘要
目的:观察调肝安神方治疗肝郁血瘀型失眠症的临床疗效及对血清脑源性神经营养因子(BDNF)、5-羟色胺(5-HT)以及核转录因子-κB(NF-κB)的影响。方法:选择2018年6月~2019年12月本院收治的肝郁血瘀型失眠症患者80例为研究对象,按照随机数表原则分为对照组、观察组。对照组患者给予佐匹克隆治疗,观察组患者给予自拟调肝安神汤治疗,治疗4周。对比两组患者临床疗效、睡眠质量、血清NF-κB、BDNF、5-HT水平,并记录两组患者治疗期间不良反应的发生情况。结果:观察组临床疗效明显优于对照组(95.00%vs 80.00%)(P<0.05);两组治疗前PSQI评分无明显差异(P>0.05),治疗后PSQI评分均下降,观察组明显低于对照组(P<0.05);治疗后观察组醒觉时间、睡眠潜伏期均短于对照组(P<0.05);治疗后观察组REM睡眠时间、睡眠总时间以及睡眠效率均优于对照组(P<0.05);两组并发症发生率比较无明显差异(23.33%vs 16.67%)(P>0.05)。结论:调肝安神方治疗肝郁血瘀型失眠症的临床疗效明显,可提高患者的睡眠质量、睡眠效率,且安全性可靠,其作用机制可能与中药可以调节机体BDNF、5-HT、NF-κB等分子生物学指标的表达水平有关。
Objective:To explore the clinical study of using Tiaogan Anshen Recipe in the treatment of liver stagnation and blood stasis insomnia and its effect on serum brain-derived neurotrophic factor(BDNF),serotonin(5-HT)and nuclear transcription factor-κB(NF-κB).Methods:Eighty patients with hepatic stasis and blood stasis type insomnia admitted in our hospital from June 2018 to December 2019 were selected as the research object,and were divided into a controlled group and an observation group according to the principle of random number table.The patients in the controlled group were treated with Zopiclone,and the patients in the observation group were given Self-made Tiaogan Anshen Decoction for 4 weeks.The clinical efficacy,sleep quality,serum NF-κB,BDNF,5-HT levels of the two groups of patients were compared,and the occurrence of adverse reactions during the treatment of the two groups of patients was recorded.Results:The clinical efficacy of the observation group was significantly better than the controlled group(95.00%vs 80.00%)(P<0.05).There was no significant difference in PSQI score between the two groups before treatment(P>0.05),PSQI score decreased after treatment,the observation group was significantly lower than the controlled group(P<0.05).After treatment,the awake time and sleep latency of the observation group were shorter than that of the controlled group(P<0.05).The REM sleep time,total sleep time and sleep efficiency of the observation group after treatment were better than the controlled group(P<0.05).There was no significant difference in the incidence of complications between the two groups(23.33%vs 16.67%)(P>0.05).Conclusion:Tiaogan Anshen Recipe is effective in treating liver stasis and blood stasis type insomnia.It can improve the quality of sleep and sleep efficiency of patients,and it is safe and reliable.The expression level of other molecular biological indicators is related.
作者
周健
任晶晶
曹刚
ZHOU Jian;REN Jingjing;CAO Gang(Department of Treatment and Prevention,Traditional Chinese Medicine Hospital of Nantong City,Nantong Jiangsu 226000,China;Department of Pharmaceutical,Traditional Chinese Medicine Hospital of Nantong City,Nantong Jiangsu 226000,China)
出处
《四川中医》
2020年第11期119-122,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
失眠症
肝郁血瘀证
中药方剂
血清指标
临床疗效
睡眠质量
Insomnia
Liver stagnation and blood stasis syndrome
Traditional Chinese medicine prescription
Serum index
Clinical efficacy
Sleep quality
