摘要
目的:分析右佐匹克隆+奥氮平对于难治性失眠症的治疗作用。方法:选取2020年12月至2022年12月间福建省安溪县城厢卫生院收治的难治性失眠症患者98例作为研究对象,按照随机数字表法随机分为观察组和对照组,每组49例。观察组在采用右佐匹克隆的基础上联合奥氮平进行治疗;对照组单纯口服右佐匹克隆进行治疗,比较治疗总有效率、睡眠质量评分、心理状态评分、血清学指标变化、不良反应率、复发率。结果:观察组的治疗总有效率明显高出对照组,差异有统计学意义(P<0.05)。治疗1 d前,2组患者睡眠质量评分、心理状态评分、血清学指标比较,差异无统计学意义(P>0.05)。治疗1个月后,观察组的睡眠质量评分低于对照组,心理状态评分低于对照组,血清学指标水平高于对照组(P<0.05)。观察组的不良反应率低于对照组,随访6个月内的复发率均低于对照组(P<0.05)。结论:在难治性失眠症患者采取右佐匹克隆治疗的前提下,联合奥氮平能够增强疗效,可改善患者的睡眠质量以及负面心理,调节其脑神经功能,减少复发情况。此外,联合用药的不良反应较少,具有较高的治疗安全性。
Objective:To analyze the treatment effect of dexzopiclone+olanzapine for refractory insomnia.Methods:A total of 98 patients with refractory insomnia,admitted to Chengxiang Health Center in Anxi County,Fujian Province from December 2020 to December 2022,were selected as research subjects,and randomly divided into observation group and control group according to the random number table method,with 49 cases in each group.The observation group was combined with olanzapine;the control group was treated with dexzaplone alone,comparing the total response rate,sleep quality score,psychological state score,change in serological index,adverse reaction rate and recurrence rate.Results:The total response rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).One day before treatment,the sleep quality score,psychological status score and serological index were compared in the 2 groups(P>0.05).After 1 month of treatment,the sleep quality score of the observation group was lower than that of the control group,the psychological state score was lower than that of the control group,and the serological index level was higher than that of the control group(P<0.05).The rate of adverse reactions in the observation group was lower than that of the control group,and the recurrence rate within 6 months of follow-up was lower than that of the control group(P<0.05).Conclusion:On the premise of right zopiclone treatment for patients with refractory insomnia,combined with olanzapine can enhance the efficacy,improve the quality of sleep and negative psychology,regulate their brain nerve function,and reduce recurrence.In addition,the combination has fewer adverse reactions and has a high therapeutic safety.
作者
杨结忠
YANG Jiezhong(Chengxiang Health Center,Anxi County,Fujian Province,Anxi 362400,China)
出处
《世界睡眠医学杂志》
2023年第11期2544-2547,共4页
World Journal of Sleep Medicine
