摘要
目的:观察舒眠胶囊联合劳拉西泮治疗失眠症的临床疗效及对患者负性情绪、血清脑源性神经营养因子(BDNF)的影响。方法:回顾性选取113例失眠症患者,根据资料中治疗方式不同分为对照组56例和观察组57例。对照组给予劳拉西泮治疗,观察组在对照组基础上加用舒眠胶囊治疗。比较2组治疗前后中医证候评分、匹兹堡睡眠质量指数(PSQI)评分、负性情绪、血清BDNF水平,并评价临床疗效和不良反应发生情况。结果:观察组总有效率为92.98%,高于对照组83.93%,差异有统计学意义(P<0.05)。治疗后,2组各项中医证候评分、PSQI各因子评分较治疗前降低,且观察组各项中医证候评分、PSQI各因子评分均低于对照组(P<0.05)。治疗后,2组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分较治疗前降低,血清BDNF水平较治疗前升高(P<0.05);且观察组SAS、SDS评分低于对照组,血清BDNF水平高于对照组(P<0.05)。结论:舒眠胶囊联合劳拉西泮治疗失眠症患者可提高临床疗效,降低中医证候评分,改善睡眠质量,减轻抑郁、焦虑等负性情绪,提高血清BDNF水平,安全性高。
Objective:To observe the clinical effect of Shumian capsules combined with lorazepam for insomnia and its effect on negative emotions and brain-derived neurotrophic factor(BDNF)in serum.Methods:A total of 113 cases of patients with insomnia were retrospectively selected and divided into the control group and the observation group according to different treatment methods,with 56 and 57 cases in each group respectively.The control group was treated with lorazepam tablets,and the observation group was additionally treated with Shumian capsules based on the treatment of the control group.Chinese medicine syndrome scores,Pittsburgh Sleep Quality Index(PSQI)scores,negative emotions and serum BDNF levels before and after treatment in the two groups were compared;the clinical effects and the incidences of adverse reactions were evaluated.Results:The total effective rate was 92.98%in the observation group,higher than that of 83.93%in the control group,the difference being significant(P<0.05).After treatment,the scores of Chinese medicine syndromes and factors in PSQI in the two groups were decreased when compared with those before treatment,and the above scores in the observation group were lower than those in the control group(P<0.05).After treatment,the scores of Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)in the two groups were decreased when compared with those before treatment,and serum BDNF levels were increased(P<0.05);the scores of SAS and SDS in the observation group were lower than those in the control group,and the serum BDNF level was higher(P<0.05).Conclusion:The therapy of Shumian capsules combined with lorazepam for patients with insomnia can improve clinical effect,reduce Chinese medicine syndrome scores,improve sleep quality,relieve depression,anxiety and other negative emotions,and increase serum BDNF levels with high safety.
作者
金艳
赖根祥
JIN Yan;LAI Genxiang
出处
《新中医》
CAS
2022年第11期80-83,共4页
New Chinese Medicine
